期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (9)
There is increased focus on developing tools to image large biomolecules, such as antibodies, within the brain using positron emission tomography (PET......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (10)
The direct electrophilic deuteration of the aromatic moiety in aromatic and aralkyl amines is reported. The acid-catalyzed deuteration is facilitated ......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (7-8)
Tritium-labeled compounds are generally less stable than their non-labeled counterparts. This requires storage at low temperatures, a constant workflo......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (11)
Positron emission tomography (PET) using O-(2-[F-18]fluoroethyl)-L-tyrosine ([F-18]FET) has shown great success in differentiating tumor recurrence fr......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; ()
Fast and straightforward incorporation of radionuclides into pharmaceutically relevant molecules is one of the main barriers to preclinical and clinic......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (9)
Trans-blood-brain barrier (BBB) delivery of therapeutic and diagnostic agents is a major challenge in the development of central nervous system (CNS) ......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (14)
Triazolinediones are an important class of derivatization agents that have found application in various research disciplines. Their unique reactivity ......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (3)
[F-18]FTC-146 was introduced as a very potent and selective sigma-1 receptor radioligand, which has shown promising application as an imaging agent fo......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; ()
Carbon-11 (C-11) is a widely used radionuclide for positron emission tomography (PET) owing to the omnipresence of carbon atoms in organic molecules. ......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (1)
This paper describes the deuterium-labelling of alkylnitroaromatics by base-catalysed exchange with deuterium oxide. As the alkyl protons alpha to the......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (2)
We describe a simple and easy pathway to synthesize nitrosamine mass spectrometry standards in good to moderate yields. N-alkylation of Boc-protected ......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (14)
The tyrosine kinase MET (hepatocyte growth factor receptor) is activated or mutated in a wide range of cancers and is often correlated with a poor pro......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (9)
Positron emission tomography (PET) is a powerful tool for imaging biological processes in the central nervous system (CNS). Designing PET radiotracers......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (3)
Since first becoming commercially available in 2018, the PET radiopharmaceutical [F-18]PSMA-1007 has been used widely for the diagnosis and staging of......
期刊： JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2023; 66 (1)
Pretargeting imaging has gained a lot of prominence, due to its excellent bioorthogonality and improved imaging contrast compared to conventional imag......
