期刊： NATURE IMMUNOLOGY, 2023; 24 (2)
Exhausted effector T cells accumulate in tumors and are the intended targets of cancer immunotherapy. New data suggest that upon infiltration and subs......
期刊： NATURE IMMUNOLOGY, 2023; 24 (3)
The cross-talk between thymocytes and thymic stromal cells is fundamental for T cell development. In humans, intrathymic development of dendritic cell......
期刊： NATURE IMMUNOLOGY, 2023; 24 (5)
The immune system is not immune to sex differences. New research now uncovers the molecular mechanisms that underlie sex-based differences during anti......
期刊： NATURE IMMUNOLOGY, 2023; 24 (5)
We engineered CD8(+) T cells with two orthogonal cytokines for adoptive cell transfer into mice with solid tumors. These cells acquired a novel synthe......
期刊： NATURE IMMUNOLOGY, 2023; 24 (7)
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A ......
期刊： NATURE IMMUNOLOGY, 2023; 24 (7)
Devant and Kagan review the biochemical and cell biological mechanisms that control gasdermin D pore-forming activity and its diverse downstream immun......
期刊： NATURE IMMUNOLOGY, 2023; 24 (7)
Despite the success of COVID-19 vaccines, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern have emerged that can cause......
期刊： NATURE IMMUNOLOGY, 2023; ()
Sharma et al. identify an early metabolic checkpoint dependent upon lactate dehydrogenase for newly activated B cells to enter germinal centers. Follo......
期刊： NATURE IMMUNOLOGY, 2023; 24 (12)
Visualization of the cellular heterogeneity and spatial architecture of the tumor microenvironment (TME) is becoming increasingly important to underst......
期刊： NATURE IMMUNOLOGY, 2023; 24 (2)
CD8(+) T cells are critical for elimination of cancer cells. Factors within the tumor microenvironment (TME) can drive these cells to a hypofunctional......
期刊： NATURE IMMUNOLOGY, 2023; 24 (1)
The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-2. However, mice with a T-cell-specific deletion of SHP-2 ......
期刊： NATURE IMMUNOLOGY, 2023; ()
Antibody dynamics resulting from sequential immunization are complex, limiting the study of concepts such as 'original antigenic sin'. Here, molecular......
