期刊： TOXICOLOGICAL SCIENCES, 2023; 191 (2)
Administration of a novel and selective small molecule integrin alpha v beta 6 inhibitor, MORF-627, to young cynomolgus monkeys for 28 days resulted i......
期刊： TOXICOLOGICAL SCIENCES, 2023; 192 (1)
Inhalation of carbon black nanoparticles (CBNPs) can impair lung tissue and cause DNA damage, but the epigenetic mechanism responsible for these effec......
期刊： TOXICOLOGICAL SCIENCES, 2023; 194 (1)
Environmental bisphenol compounds like bisphenol F (BPF) are endocrine-disrupting chemicals (EDCs) affecting adipose and classical endocrine systems. ......
期刊： TOXICOLOGICAL SCIENCES, 2023; ()
Harmful algal blooms (HABs) release toxic compounds in water and are increasing in frequency worldwide. The neurotoxin bmethylamino-L-alanine (BMAA) i......
期刊： TOXICOLOGICAL SCIENCES, 2023; 193 (2)
In November of 2021, the European Food Safety Authority (EFSA) released a draft scientific opinion on bisphenol A (BPA) exposure and health outcomes r......
期刊： TOXICOLOGICAL SCIENCES, 2023; 196 (1)
To minimize the occurrence of unexpected toxicities in early phase preclinical studies of new drugs, it is vital to understand fundamental similaritie......
期刊： TOXICOLOGICAL SCIENCES, 2023; 191 (1)
Determining the potential cardiotoxicity and pro-arrhythmic effects of drug candidates remains one of the most relevant issues in the drug development......
期刊： TOXICOLOGICAL SCIENCES, 2023; 192 (1)
Arsenic exposure is correlated with atherosclerosis in epidemiological studies and in animal models. We have previously shown that arsenic exposure en......
期刊： TOXICOLOGICAL SCIENCES, 2023; 193 (1)
We present a mechanistic machine-learning quantitative structure-activity relationship (QSAR) model to predict mammalian acute oral toxicity. We train......
期刊： TOXICOLOGICAL SCIENCES, 2023; ()
Phthalates are compounds used in consumer and medical products worldwide. Phthalate exposure in women has been demonstrated by detection of phthalate ......
期刊： TOXICOLOGICAL SCIENCES, 2023; 197 (1)
Lapatinib, an oral tyrosine kinase inhibitor used as a first-line treatment for HER2-positive breast cancer, has been reported to be associated with h......
期刊： TOXICOLOGICAL SCIENCES, 2023; 191 (2)
Since initial regulatory action in 2010 in Canada, bisphenol A (BPA) has been progressively replaced by structurally related alternative chemicals. Un......
期刊： TOXICOLOGICAL SCIENCES, 2023; 192 (1)
Developmental neurotoxicity (DNT) is a potential hazard of chemicals. Recently, an in vitro testing battery (DNT IVB) was established to complement ex......
期刊： TOXICOLOGICAL SCIENCES, 2023; ()
Cell death is a fundamental biological process, and its fine-tuned regulation is required for life. However, the complexity of regulated cell death is......
期刊： TOXICOLOGICAL SCIENCES, 2023; ()
Chemical risk assessors use physiologically based pharmacokinetic (PBPK) models to perform dosimetric calculations, including extrapolations between e......
