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Nicaraven inhibits TNF alpha-induced endothelial activation and inflammation through suppression of NF-kappa B signaling pathway

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (8)

Inflammation-induced activation and dysfunction of endothelial cells play an important role in the pathology of multiple vascular diseases. Nicaraven,......

Mild hyperhomocysteinemia induces blood-brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (9)

This study explored the potential effects of mild hyperhomocysteinemia (HHcy) on the blood-brain barrier (BBB) and neuroinflammation. Seven-week-old m......

Lipopolysaccharide induces BV2 microglial cell migration via a decrease in SET8 expression

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (6)

Excessively activated microglia exhibit increased migration, resulting in tissue damage and chronic inflammation. Src was confirmed to play an importa......

Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (9)

Alamandine (ALA) and its receptor MrgD were recently identified as components of the renin-angiotensin system, which confer protection against cardio-......

Cpt1a promoted ROS-induced oxidative stress and inflammation in liver injury via the Nrf2 HO-1 and NLRP3 inflammasome signaling pathway

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (5)

Various liver diseases caused by liver damage seriously affect people's health. The purpose of this study was to clarify the effects and the mechanism......

Rosuvastatin corrects oxidative stress and inflammation induced by LPS to attenuate cardiac injury by inhibiting the NLRP3/TLR4 pathway

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (9)

Rosuvastatin has been found to possess antioxidant and anti-inflammatory properties. The aim of the current study was to evaluate whether rosuvastatin......

Cyanidin-3-O-glucoside attenuates high glucose-induced podocyte dysfunction by inhibiting apoptosis and promoting autophagy via activation of SIRT1/AMPK pathway

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (6)

Diabetic nephropathy (DN) is a common and complicated chronic kidney disease around the world. To elucidate and find effective therapies of DN is of v......

Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (9)

Vascular endothelial cell senescence is a leading cause of age-associated diseases and cardiovascular diseases. Interventions and therapies targeting ......

Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (9)

Metformin has been demonstrated to be beneficial for the treatment of an impaired myocardium as a result of ischemia/reperfusion (I/R) injury, and miR......

Tetrahydroxystilbene glucoside alleviates angiotensin II induced HUVEC senescence via SIRT1

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (4)

Tetrahydroxystilbene glucoside (TSG), an active ingredient of Polygonum multiflorum, has been known for certain anti-aging effects. In this study, the......

Metformin alleviates hydrogen peroxide-induced inflammation and oxidative stress via inhibiting P2X7R signaling in spinal cord tissue cells neurons

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (8)

Metformin, the first medication that is often prescribed for the treatment of type 2 diabetes mellitus, was recently found to be neuroprotective. To s......

Differences between exhausted CD8(+) T cells in hepatocellular carcinoma patients with and without uremia

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (4)

The purpose of this study was to explore the differences between exhausted CD8(+) T cells in hepatocellular carcinoma (HCC) patients with and without ......

Exchange proteins directly activated by cAMP mediate cardiac repolarization and arrhythmogenesis during chronic heart failure

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (7)

Most sudden cardiac death in chronic heart failure (CHF) is caused by malignant ventricular arrhythmia (VA); however, the molecular mechanism remains ......

The screening of albumin as a key serum component in preventing release of neutrophil extracellular traps by selectively inhibiting mitochondrial ROS generation

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (4)

Neutrophil extracellular traps (NETs) are extracellular DNA webs released from neutrophils to mediate the host antimicrobial defense. As NETs could al......

p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2021; 99 (4)

Hypertrophic scar (HS) results from abnormal wound healing, accompanied by excessive hypercellularity, migration, and extracellular matrix (ECM) depos......

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