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A quantitative systems pharmacology model of hyporesponsiveness to erythropoietin in rats

期刊: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2021; 48 (5)

Recombinant human erythropoietin (rHuEPO) is effective in managing chronic kidney disease and chemotherapy-induced anemia. However, hyporesponsiveness......

Constant infusion case of one compartment pharmacokinetic model with simultaneous first-order and Michaelis-Menten elimination: analytical solution and drug exposure formula

期刊: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, ; ()

The main objective of this article is to propose the closed-form solution of one-compartment pharmacokinetic model with simultaneous first-order and M......

Disease progression model of 4T1 metastatic breast cancer

期刊: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2020; 47 (1)

Cancer metastasis is the main cause of death in various types of cancer. However, in the field of pharmacometrics, cancer disease progression models f......

Concentration-response modeling of ECG data from early-phase clinical studies to assess QT prolongation risk of contezolid (MRX-I), an oxazolidinone antibacterial agent

期刊: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2019; 46 (6)

The effects of contezolid (MRX-I, an oxazolidinone antibacterial agent) on cardiac repolarization were evaluated retrospectively using a population mo......

JIF:2.91

A modeling and simulation-based assessment of the impact of confounding factors on the readout of a sildenafil survival trial in pulmonary arterial hypertension

期刊: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2019; 46 (5)

Sildenafil (REVATIO (R)) was approved for the treatment of adult Pulmonary Arterial Hypertension (PAH) in the US and the EU. A pediatric study has bee......

JIF:2.91

Statistical analysis of one-compartment pharmacokinetic models with drug adherence

期刊: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2022; 49 (2)

Pharmacokinetics is a scientific branch of pharmacology that describes the time course of drug concentration within a living organism and helps the sc......

JIF:2.072

Chemotherapeutic dosing implicated by pharmacodynamic modeling of in vitro cytotoxic data: a case study of paclitaxel

期刊: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2017; 44 (5)

Conventional maximum tolerated doses (MTD) in chemotherapy are recently challenged by an alternative dosing method with low doses and high dosing freq......

JIF:2.2

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