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NEJM:左旋多巴对帕金森疾病的改善研究

2019-01-24 zhangfan MedSci原创

研究认为,左旋多巴联合甲基多巴肼对早期帕金森患者无疾病治疗作用

左旋多巴是缓解帕金森病患者临床症状的重要药物,近日研究人员就左旋多巴对疾病本身的治疗效果进行了考察。

早期帕金森患者参与研究,随机接受每日3次,每次100mg的左旋多巴+每日3次,每次25mg的甲基多巴肼持续80周(提前治疗组)或先接受40周的安慰剂,随后接受40周的左旋多巴+甲基多巴肼(延迟治疗组)。研究的主要终点为80周帕金森病统一评分差异(UPDRS,0-176)。次要终点为症状进展,比较提前治疗组4-40周、44-80周,延迟治疗组44-80周UPDRS得分差异,非劣性边界为周得分差异0.055分。

445名患者参与研究,其中早期治疗组222人,延迟治疗组223人,基线UPDRS得分分别为28.1和29.3分。80周各组UPDRS分别变化了-1.0±13.1分和-2.0±13.0分,无显著性差异,左旋多巴无疾病治疗效果。早期治疗组4-40周,每周UPDRS得分增加0.04±0.23,44-80周为0.10±0.25,延迟治疗组44-80周每周UPDRS得分增加0.03±0.28,表现出非劣性。组间患者运动障碍和左旋多巴相关运动反应无显著性差异。

研究认为,左旋多巴联合甲基多巴肼对早期帕金森患者无疾病治疗作用。

原始出处:

Constant V.M. Verschuur et al. Randomized Delayed-Start Trial of Levodopa in Parkinson's Disease.N Engl J Med,January 24, 2019.

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    2019-02-26 wxl882001

    了解一下

    0

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    2019-02-06 wxl882001

    了解一下

    0

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