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JAMA:不开胸主动脉瓣换瓣术后,用RAS抑制剂可改善预后

2018-12-07 朱柳媛 中国循环杂志

12月4日,一项发表在JAMA上的美国研究表明,对于经导管主动脉瓣置换(TAVR)术后患者,出院后服用肾素血管紧张素系统(RAS)抑制剂可降低因心力衰竭住院和死亡的风险。

12月4日,一项发表在JAMA上的美国研究表明,对于经导管主动脉瓣置换(TAVR)术后患者,出院后服用肾素血管紧张素系统(RAS)抑制剂可降低因心力衰竭住院和死亡的风险。

这项研究中的21 312例患者来自于美国胸外科医师学会/美国心脏病学会经导管瓣膜治疗注册登记研究,住院时近40%接受RAS抑制剂治疗,包括血管紧张素转换酶抑制剂(ACEI)和血管紧张素Ⅱ受体拮抗剂(ARB)。经倾向匹配评分后,15 896例患者进入最终分析。

结果显示,出院1年时服用RAS抑制剂的患者因心衰住院和死亡的风险比没有用RAS抑制剂者分别降低14%和18%。

这主要是左心室射血分数正常的患者获益。分析表明,在射血分数保留的患者中,服用RAS抑制剂者1年死亡风险降低了22%,而左心室射血分数降低的患者无此获益(HR=0.95, 95% CI: 0.81~1.12)。

研究者还发现,出院后服用RAS抑制剂的患者健康状况(通过Kansas城市心肌病问卷评估)优于没有用RAS抑制剂者。

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    2019-11-16 jklm09
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