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Clinical Gastroenterology H: 2型糖尿病患者易患严重肝病

2019-11-28 不详 MedSci原创

2型糖尿病是肝硬化和肝细胞癌发展的危险因素。但是还没有大型队列进行验证,本项研究旨在进行这方面的探讨。

背景与目标
2型糖尿病是肝硬化和肝细胞癌发展的危险因素。但是还没有大型队列进行验证,本项研究旨在进行这方面的探讨。

方法
《国家糖尿病登记册》纳入了瑞典约90%的2型糖尿病患者的数据。研究人员利用此数据库进行了本项研究。同时研究人员按年龄,性别和地域进行了健康对照匹配。本项研究总共纳入了406770名2型糖尿病患者和2033850名对照组,随访时间为21596934人年。我们使用基于人群的登记簿来确定严重肝病的发生率,严重肝病的定义为随访期间诊断为肝细胞癌,肝硬化,代偿失调,肝衰竭和/或因肝病导致的死亡。进行了Cox回归以估计严重肝病的风险并检查2型糖尿病患者的危险因素。

结果
与对照组相比,2型糖尿病患者发生严重肝病的风险增加(危险比,2.28; 95%CI,2.21–2.36)。与2型糖尿病患者的严重肝病相关的危险因素是较高的年龄,男性,高血压,较高的体重指数,较低的肾小球滤过率,微量白蛋白尿和吸烟。他汀类药物与降低严重肝病的风险有关。

结论
2型糖尿病患者罹患严重肝病的风险增加。了解危险因素可能有助于识别患有严重肝病的高风险的2型糖尿病患者。

原始出处:
Karl Bjrkstrm. Et al. Risk Factors for Severe Liver Disease in Patients With Type 2 Diabetes. Clinical Gastroenterology H.2019.

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    2020-04-13 许安
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    2019-11-30 zll0628
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    2019-11-29 misszhang

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