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Eur Heart J:急性心肌梗死住院时间与院内死亡率之间的关系

2019-02-10 xing.T MedSci原创

由此可见,几乎没有证据支持AMI住院时间和院内死亡率之间的关联;合并疾病和治疗可能解释院内死亡率的差异。

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在明确急性心肌梗死(AMI)住院时间与住院死亡率之间的关系。

该研究纳入了2004年1月1日至2013年3月31日期间在英格兰和威尔士的243家医院因ST段抬高心肌梗死(STEMI)和非STEMI(NSTEMI)住院的患者。结局指标是院内死亡率。使用多重Logistic回归、反向概率加权倾向得分和工具变量分析估计24小时时间内通过6个4小时时间段的院内死亡率调整后比值比(OR)。

在615035例患者中[中位年龄70.0岁,四分位数范围为59.0-80.0岁; 406519(66.0%)为男性],有52777名(8.8%)患者住院死亡。在晚上,NSTEMI患者出现并发症更频繁,并且对于STEMI患者从症状发作至再灌注时间更长。对于STEMI患者未调整的院内死亡率在20:00至23:59之间最高[4小时期间范围为8.4-9.9%,与00:00-03:59比较OR为1.13,95%置信区间(CI)为1.07-1.20],并且对于NSTEMI在12:00-15:59之间死亡最高(8.0-8.8%; 与00:00-03:59比较的OR为1.07,95%CI为1.03-1.12)。然而,这些差异仅在研究的早期阶段才明显,并且通过调整人口统计学指标、合并症和临床表现而减弱。在调整所提供的急性临床治疗后,差异无统计学意义。

由此可见,几乎没有证据支持AMI住院时间和院内死亡率之间的关联;合并疾病和治疗可能解释院内死亡率的差异。

原始出处:


Jianhua Wu.et al.Association between time of hospitalization with acute myocardial infarction and in-hospital mortality.Eur Heart J.https://doi.org/10.1093/eurheartj/ehy835

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    2019-02-12 zhaojie88
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    2019-02-12 slcumt

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