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Clin Oral Investig:牙周治疗是否会影响全身的血小板活化?

2020-11-08 MedSci原创 MedSci原创

牙周炎与全身炎症、血小板激活升高和心血管疾病风险增强有关,而牙周治疗可减轻组织炎症,对口腔生物膜和牙齿健康显示出理想的效果。但保守治疗时龈下脱屑可导致局部创伤和短暂性菌血症,可能影响这些患者的心血管风

牙周炎与全身炎症、血小板激活升高和血管疾病风险增强有关,而牙周治疗可减轻组织炎症,对口腔生物膜和牙齿健康显示出理想的效果。但保守治疗时龈下脱屑可导致局部创伤和短暂性菌血症,可能影响这些患者的心血管风险。因此,我们研究了牙周治疗对全身血小板活化的影响。

采用前瞻性研究设计,纳入26名患者,接受牙周治疗,并在干预前和干预后立即分析患者血液中的血小板活化标志物(流式细胞仪分析P-选择素、CD63和CD40L表面表达、整合素αIIbβ3激活和纤维蛋白原结合、血小板内活性氧的产生、血小板-白细胞聚集形成和血小板内血管扩张剂刺激的磷酸蛋白磷酸化),以响应二磷酸腺苷(ADP)。

 

结果显示,基础血小板活化水平在牙周治疗的反应中基本没有改变。也没有观察到血小板反应性对不同浓度的血小板激动剂ADP反应的显著变化。

综上所述,该研究结果表明,龈下脱屑不会导致相关的血小板活化增强。因此,增强的血小板活化似乎不太可能是一个诱发因素,增加了对龈下剥离反应的血小板介导的血栓事件的短期风险。

 

原始出处:

 

Markus Laky, Isabella Anscheringer, et al., Periodontal treatment does not result in detectable platelet activation in vivo. Clin Oral Investig. 2020 May;24(5):1853-1859. doi: 10.1007/s00784-019-03049-x. 

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    2021-08-02 小几洁
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