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Int J Pediatr Otorhinolaryngol:鼻炎与咽鼓管功能障碍是否相关?

2023-04-08 AlexYang MedSci原创 发表于上海

调查了美国青少年具有全国代表性的样本中,鼻炎与咽鼓管功能障碍之间的关系。

在普通人群中,下鼻甲慢性肥大是一种常见的情况,且通常与合并症有关,如过敏性疾病和鼻粘膜血管运动亢进。尽管长期以来临床上一直认为鼻炎与咽鼓管功能障碍(ETD)之间存在关系,但缺乏支持这种联系的人群证据,特别是在青少年中。

近期,来自美国的研究人员在《Int J Pediatr Otorhinolaryngol》上发表文章,调查了美国青少年具有全国代表性的样本中,鼻炎与咽鼓管功能障碍之间的关系

研究人员对2005-2006年全国健康和营养调查数据进行了横断面分析(n=1955,12-19岁)。根据血清IgE气源过敏原阳性,将鼻炎(过去12个月内自我报告的枯草热和/或鼻部症状)分层为过敏性(AR)或非过敏性鼻炎(NAR)。记录了耳部疾病和手术史。鼓室测量按类型(A、B、C)分类。多变量逻辑回归法用来检验鼻炎和ETD的关联。

结果发现,在美国青少年中,29.4%报告有鼻炎(NAR 38.9%,AR 61.1%),14.0%鼓膜测量异常。患有鼻炎的青少年更有可能报告有≥3次的耳部感染史(NAR: OR 2.40, 95%CI: 1.72-3.34, p<0.001; AR: OR 1.89, 95%CI: 1.21-2.95, p=0.008)和鼓室造口管植入(NAR: 与没有鼻炎的人相比,OR 3.53,95%CI:2.07-6.03,p<0.001;AR:OR 1.91,95%CI:1.24-2.94,p=0.006)。鼻炎和鼓膜测量异常之间没有关联(NAR:p=0.357;AR:p=0.625)。

鼻炎和鼓室测量异常的多变量逻辑回归分析

综上所述,在美国青少年中,NAR和AR都与频繁的耳部感染和鼓膜造口术置管史有关,支持了与ETD的关联,且NAR与ETD的关联最强,表明特定的炎症机制可能参与了这种情况,并有可能解释为什么传统的AR治疗方法对ETD基本无效

原始出处:

Dara R Adams, Nicholas R Rowan, Sandra Y Lin et al. Are rhinitis and Eustachian tube dysfunction associated in United States adolescents? Int J Pediatr Otorhinolaryngol. Mar 2023

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2124538, encodeId=7c52212453895, content=鼻炎与咽鼓管功能障碍(ETD)之间存在关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Sun Apr 09 06:20:53 CST 2023, time=2023-04-09, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2124532, encodeId=d87c21245327b, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b08e8469269, createdName=ms4000000512201075, createdTime=Sun Apr 09 05:28:57 CST 2023, time=2023-04-09, status=1, ipAttribution=吉林省), GetPortalCommentsPageByObjectIdResponse(id=2124524, encodeId=66d3212452429, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Apr 08 23:37:23 CST 2023, time=2023-04-08, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2124584, encodeId=c2612124584bf, content=`"学学刁习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Sun Apr 09 14:02:48 CST 2023, time=2023-04-09, status=1, ipAttribution=山东省)]
    2023-04-09 jshbyywk2008 来自河北省

    鼻炎与咽鼓管功能障碍(ETD)之间存在关系

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2124538, encodeId=7c52212453895, content=鼻炎与咽鼓管功能障碍(ETD)之间存在关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Sun Apr 09 06:20:53 CST 2023, time=2023-04-09, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2124532, encodeId=d87c21245327b, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b08e8469269, createdName=ms4000000512201075, createdTime=Sun Apr 09 05:28:57 CST 2023, time=2023-04-09, status=1, ipAttribution=吉林省), GetPortalCommentsPageByObjectIdResponse(id=2124524, encodeId=66d3212452429, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Apr 08 23:37:23 CST 2023, time=2023-04-08, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2124584, encodeId=c2612124584bf, content=`"学学刁习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Sun Apr 09 14:02:48 CST 2023, time=2023-04-09, status=1, ipAttribution=山东省)]
    2023-04-09 ms4000000512201075 来自吉林省

    不错,学习了。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2124538, encodeId=7c52212453895, content=鼻炎与咽鼓管功能障碍(ETD)之间存在关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Sun Apr 09 06:20:53 CST 2023, time=2023-04-09, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2124532, encodeId=d87c21245327b, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b08e8469269, createdName=ms4000000512201075, createdTime=Sun Apr 09 05:28:57 CST 2023, time=2023-04-09, status=1, ipAttribution=吉林省), GetPortalCommentsPageByObjectIdResponse(id=2124524, encodeId=66d3212452429, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Apr 08 23:37:23 CST 2023, time=2023-04-08, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2124584, encodeId=c2612124584bf, content=`"学学刁习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Sun Apr 09 14:02:48 CST 2023, time=2023-04-09, status=1, ipAttribution=山东省)]
    2023-04-08 医鸣惊人 来自山西省

    认真学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2124538, encodeId=7c52212453895, content=鼻炎与咽鼓管功能障碍(ETD)之间存在关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Sun Apr 09 06:20:53 CST 2023, time=2023-04-09, status=1, ipAttribution=河北省), GetPortalCommentsPageByObjectIdResponse(id=2124532, encodeId=d87c21245327b, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b08e8469269, createdName=ms4000000512201075, createdTime=Sun Apr 09 05:28:57 CST 2023, time=2023-04-09, status=1, ipAttribution=吉林省), GetPortalCommentsPageByObjectIdResponse(id=2124524, encodeId=66d3212452429, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sat Apr 08 23:37:23 CST 2023, time=2023-04-08, status=1, ipAttribution=山西省), GetPortalCommentsPageByObjectIdResponse(id=2124584, encodeId=c2612124584bf, content=`"学学刁习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Sun Apr 09 14:02:48 CST 2023, time=2023-04-09, status=1, ipAttribution=山东省)]
    2023-04-09 八骏奔腾 来自山东省

    `"学学刁习

    0

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