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JACC:严重肢体缺血的外周动脉疾病患者的动脉病理变化

2018-10-30 MedSci MedSci原创

严重的肢体缺血(CLI)是外周动脉疾病(PAD)的主要并发症之一。本研究的目的旨在评估CLI患者膝盖上和膝盖下标本的PAD病理变化。本研究共纳入了95例外周动脉疾病患者的121个截肢标本,其中75例患者存在CLI,截肢标本的股动脉和腘动脉(FEM-POP)与膝下动脉(INFRA-POP)被单独进行病理分析。最终共分析了299条动脉,在239条来自CLI患者的动脉中,动脉粥样斑块在FEM-POP中更

严重的肢体缺血(CLI)是外周动脉疾病(PAD)的主要并发症之一。本研究的目的旨在评估CLI患者膝盖上和膝盖下标本的PAD病理变化。

本研究共纳入了95例外周动脉疾病患者的121个截肢标本,其中75例患者存在CLI,截肢标本的股动脉和腘动脉(FEM-POP)与膝下动脉(INFRA-POP)被单独进行病理分析。最终共分析了299条动脉,在239条来自CLI患者的动脉中,动脉粥样斑块在FEM-POP中更常见(67.6% vs 38.5%),在这239条动脉中,165 (69%)条存在≥70%的狭窄,慢性管腔血栓在动脉粥样硬化斑块不显着的动脉中更常见(OR: 16.7; p = 0.0002),在INFRA-POP更常见(OR: 2.14; p = 0.0041)。急性血栓栓塞在INFRA-POP中更少见(OR: 0.27; p = 0.0067),有170条动脉存在中层钙化。

研究结果显示,严重的肢体缺血动脉的病理表现呈进展性,膝下动脉尤为明显,提示外周动脉疾病向肢体缺血是一个进展的过程。

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    2019-07-08 hbwxf
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    2018-10-30 天地飞扬

    了解一下,谢谢分享!

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