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Neurology:复发缓解型多发性硬化精神疾病风险评估

2017-08-29 zhangfan MedSci原创

研究认为对于复发缓解型多发性硬化患者,鞘内炎症可导致情绪变化,对于疾病的复发预测具有一定的临床指导意义

近日研究人员对多发性硬化患者神经炎症过程及其对精神分裂症预后的影响进行了考察。研究共招募了405名复发缓解型多发性硬化患者,通过贝克氏抑郁症(BDI-II)以及焦虑状态特质(STAI-Y)评估法对患者进行精神疾病检查,通过MRI考察患者炎症水平。对于111名未接受治疗的患者测试其脑脊液细胞激素水平。研究发现,复发患者相对于缓解患者的精神疾病风险提高,但焦虑状态不显著。患者间心理学指标、MRI炎症水平以及临床炎症对情绪障碍的影响差异不显著。对于未治疗患者,脑脊液白介素2水平与焦虑特征得分相关,肿瘤坏死因子-α和白细胞介素-1β水平与精神疾病状态评分相关。研究发现,情绪障碍与临床炎症有关,心理学异常状态对临床检查有指导作用。研究认为对于复发缓解型多发性硬化患者,鞘内炎症可导致情绪变化,对于疾病的复发预测具有一定的临床指导意义。原始出处:Silvia Rossi et al. Neuroinflammation drives anxiety and depression in relapsing-remitting multiple sclerosis. Neurology. August

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    2017-09-22 jml2009
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    2018-07-05 yinhl1978
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    2017-08-30 littlepiggy

    情绪变化反映脑内炎症水平

    0

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    2017-08-30 meiliwuxian

    学习一下

    0

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