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Circulation:主动脉根部扩张术(ARE)可安全辅助主动脉瓣置换术(AVR)的进行!

2018-04-15 MedSci MedSci原创

在主动脉瓣置换术(AVR)过程中进行主动脉根部扩展术(ARE)可用于更大的假体植入术,也可能会是经导管瓣膜置换术中外科AVR的重要辅助手段。但目前AVR手术叠加ARE手术所增加的手术风险尚未建立。现Rodolfo V. Rocha等人对AVR叠加ARE的患者早期预后进行评估。1990年1月-2014年8月,共7039位患者接受AVR(AVR+ARE 1854位、AVR 5185位)。排除主动脉夹层

在主动脉瓣置换术(AVR)过程中进行主动脉根部扩展术(ARE)可用于更大的假体植入术,也可能会是经导管瓣膜置换术中外科AVR的重要辅助手段。但目前AVR手术叠加ARE手术所增加的手术风险尚未建立。现Rodolfo V. Rocha等人对AVR叠加ARE的患者早期预后进行评估。

1990年1月-2014年8月,共7039位患者接受AVR(AVR+ARE 1854位、AVR 5185位)。排除主动脉夹层和主动脉心内膜炎的患者。中位年龄65±14岁,63%为男性。

采用AVR+ARE的多为女性(46% vs 34%,p<0.001),而且既往发生心脏外科手术(18% vs 12%,p<0.001)、慢性阻塞性肺疾病(慢阻肺)(5% vs 3%,p=0.004)、紧急状况(6% vs 4%,p=0.001)的比例也更高,NYHA评分更差(p<0.001)。大多数患者采用人造生物瓣膜(AVR+ARE:73.4% vs AVR:73.3%,p=0.98),并接受心脏手术(AVR+ARE:68% vs AVR:67%,p=0.31)。与进行AVR的患者相比,进行AVR+ARE手术的患者所移植的假体平均尺寸稍小(23.4±2.1 vs 24.1±2.3,p<0.001)。AVR+ARE后的院内死亡率要更高(4.3%  vs 3.0%,p=0.008),但当队列只局限于接受主动脉瓣置换术有无根部扩张时,死亡率无统计学差异(AVR+ARE:1.7% vs AVR:1.1%,p=0.29)。根据基础特征校准后,AVR+ARE与AVR相比,与院内死亡风险增加没有关联(危险比 1.03,95% CI 0.75-1.41,p=0.85)。而且,AVR+ARE与术后副反应事件风险增加也无关联。

迄今为止,该研究为包含数据量最多的分析,本研究结果提示,ARE与死亡或副反应风险增加没有关系。外科ARE是现代AVR的一种安全的辅助手段。

原始出处:

Rodolfo V. Rocha,et al.Surgical Enlargement of the Aortic Root Does Not Increase the Operative Risk of Aortic Valve Replacement.Circulation. April 10, 2018.https://doi.org/10.1161/CIRCULATIONAHA.117.030525

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    2018-06-23 lsj637
  3. 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    2019-03-11 yxch48
  4. 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  5. 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  6. 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  7. 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  8. 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  9. 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time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306061, encodeId=bf2d3060611d, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 15 16:31:42 CST 2018, time=2018-04-15, status=1, ipAttribution=)]
    2018-04-15 虈亣靌

    嘿嘿.真是让人耳目一新.感觉望尘莫及似的.学习了

    0

  10. 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time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=306061, encodeId=bf2d3060611d, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Apr 15 16:31:42 CST 2018, time=2018-04-15, status=1, ipAttribution=)]
    2018-04-15 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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对于进行主动脉瓣置换术的患者,与标准主动脉插管相比,脑栓塞保护装置未能显著降低7天内中枢神经系统梗死风险,对于术后谵妄、认知以及中风症状的改善需要进行长期的监测确认。

CHC2017:TAVR 会成为主动脉瓣疾病主要手段吗?

在昨天进行的结构性心脏病论坛上,来自德国的瓣膜介入治疗先驱Eberhard Grube 教授和阜外医院杨跃进教授对经导管主动脉瓣置换术(TAVR)临床治疗现状及进展做了精彩报告。Grube 教授认为,TAVR 的很多问题已得到了较好的解决,随着技术的进一步进展,临床研究数据的进一步完善,TAVR 有望成为主动脉瓣疾病患者的主要治疗选择。

Circ: Cardiovasc Inte:小主动脉瓣环患者中下一代自扩张与球囊扩张TAVR短期疗效和血流动力学比较

与SAPIEN 3相比,经ACURATE新型瓣膜经导管主动脉瓣置换术后瓣环梯度较低,患者假体-患者不匹配率更低。

Lancet:心脏手术围术期心肌损伤的节律变化及其预防

研究发现,主动脉瓣置换术的围手术期心肌损伤存在昼夜节律差异,下午手术患者发生严重围手术期心肌损伤的风险低于上午手术

Circulation:手术扩大主动脉根部不会增加主动脉瓣置换的手术风险

在这项迄今最大的分析中,ARE与死亡率或不良事件风险升高无关。

JACC:经皮自膨式主动脉瓣置换术的疗效和安全性研究

目前,经皮二代自膨式主动脉瓣置换术的临床预后尚缺乏大型临床研究的数据。近日,在国际心血管权威杂志JACC上发表了一篇旨在记录和评估在严重的主动脉瓣狭窄患者中应用二代自膨式心脏瓣膜(THV)行经皮主动脉瓣置换术(TAVR)的预后疗效的临床研究。本研究是多中心回顾性研究,自2016年1月至2016年12月共纳入1038例应用THV行TAVR的主动脉瓣狭窄患者,平均年龄是81.8 ± 6.2岁,女性占6

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