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JACC:健康人群心肺健康状况与死亡率的相关性研究

2018-10-31 MedSci MedSci原创

心肺健康(CRF)和死亡率的关系已经有许多研究证实,然而大部分研究都是通过估计CRF得出的结论。本研究的目的旨在健康人群中通过心肺运动(CPX)测试评估心肺健康与全因、心血管和癌症死亡率的关系。本研究纳入了4137名健康对象(男性为2326名,女性为1811名,平均年龄42.8 ± 12.2岁),并通过CPX检测了基线的CRF水平,经过24.2 ± 11.7年时间的随访,评估了死亡率。随访期间,7

心肺健康(CRF)和死亡率的关系已经有许多研究证实,然而大部分研究都是通过估计CRF得出的结论。本研究的目的旨在健康人群中通过心肺运动(CPX)测试评估心肺健康与全因、血管和癌症死亡率的关系。

本研究纳入了4137名健康对象(男性为2326名,女性为1811名,平均年龄42.8 ± 12.2岁),并通过CPX检测了基线的CRF水平,经过24.2 ± 11.7年时间的随访,评估了死亡率。随访期间,727名对象死亡(男性为524名,女性为203名),CPX检测的CRF与全因、血管和癌症死亡率呈负相关,低CRF与高的死亡率呈相关性(全因:[HR]: 1.73; 95% [CI]: 1.20 - 3.50;心血管:HR: 2.27; 95% CI: 1.20 - 3.49;癌症:HR: 2.07; 95% CI: 1.18 - 3.36)。

研究结果显示,鉴于心肺健康对死亡风险的预测影响,高度建议心肺运动测试在健康人群中的使用。

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    2019-04-23 hbwxf
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    2019-01-09 aids222
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