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ANN ONCOL:酒精和烟草摄入可以预测头颈部肿瘤患者死亡率

2017-11-30 MedSci MedSci原创

ANN ONCOL近期发表了一篇文章,研究人口特征,诊断前生活习惯和临床数据是否与头颈部肿瘤患者总生存和头颈部肿瘤特异性生存有关。

ANN ONCOL近期发表了一篇文章,研究人口特征,诊断前生活习惯和临床数据是否与头颈部肿瘤患者总生存和头颈部肿瘤特异性生存有关。作者汇总了5个头颈部肿瘤的研究共4759例患者进行分析。使用Cox模型纳入已报道的显着影响生存的因素后分析风险比和95%置信区间。研究结果表明,所有头颈部肿瘤患者5年总生存率为51.4%:口腔癌50.3%,口咽癌41.1%,下咽癌35.0%,喉癌63.9%。当考虑头颈部肿瘤特异性生存时,所有患者5年生存率为57.4%:口腔癌54.6%,口咽癌45.4%,下咽癌37.1%,喉癌72.3%。诊断时高龄以及肿瘤分期晚是总生存和头颈部肿瘤特异性生存的不良预后因素。在喉癌中,受教育水平低是总生存的不良预后因素,饮酒量对患者总生存和头颈部肿瘤特异性生存均为预后因素。在口咽癌中,吸烟状态是总生存的独立预后因素。在口腔癌中,吸烟量同样是患者总生存的独立预后因素。文章最后认为,不同部位头颈部肿瘤总生存和头颈部肿瘤特异性生存不同。诊断前吸烟是口腔癌和口咽癌患者总生存的预后因素,诊断前饮酒是喉癌患者总生存和头颈部肿瘤特异性生存的预后因素。在喉癌患者中,教育水平低是总生存的不良预后

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    2018-01-31 minlingfeng
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    2017-12-02 mnda
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    2017-12-02 wshxjq
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