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Diabetic Med:患有前驱糖尿病的青少年的心血管危险因素

2018-11-01 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于患有前驱糖尿病的青少年的心血管危险因素的研究。 患有2型糖尿病的青少年更可能有心血管疾病(CVD)风险因素,但在患有前驱糖尿病的青少年中关于此类的数据目前仍然很少。研究人员描述了美国患有前驱糖尿病的青少年的CVD危险因素,并将这些风险因素的水平与正常葡萄糖的青少年进行了比较。 2005-2014年全国健康和营养检查调查是一

近日,国际杂志 《Diabetic Med》上在线发表一项关于患有前驱糖尿病的青少年的血管危险因素的研究。

患有2糖尿病的青少年更可能有血管疾病(CVD)风险因素,但在患有前驱糖尿病的青少年中关于此类的数据目前仍然很少。研究人员描述了美国患有前驱糖尿病的青少年的CVD危险因素,并将这些风险因素的水平与正常葡萄糖的青少年进行了比较。

2005-2014年全国健康和营养检查调查是一项具有全国代表性的横断面调查,其中包括年龄在12-19岁排除糖尿病的2843名的青少年。前驱糖尿病基于HbA 1c,空腹血浆葡萄糖或2小时血浆葡萄糖。研究人员使用适合年龄的临界点确定了青少年的心脏代谢风险因素。同时还计算了与正常血糖水平相比,与前驱糖尿病相关的这些结果的优势比(OR)和95%可信区间(CI)。

研究显示,前驱糖尿病的加权患病率为17.4%。校正后,前驱糖尿病(与正常葡萄糖相比)与肥胖(OR 1.86,95CI 1.35-2.55),低HDL-胆固醇OR 1.62,95CI 1.08-2.44),高甘油三酯(OR 1.61,95%) CI 1.12-2.30)和肝转氨酶升高(OR 2.09,95CI 1.19-3.67)相关,但与高血压OR 1.77,95CI 0.88-3.54),总胆固醇升高(OR 1.30,95CI 0.82-2.06 ),LDL-胆固醇升高(OR 1.59,95CI 0.88-2.88)或白蛋白尿(OR 1.24,95CI 0.76-2.02)无关。

研究表明,与葡萄糖正常的青少年相比,患有前驱糖尿病的美国青少年更容易患有肥胖,低HDL-胆固醇,高甘油三酯和升高的肝转氨酶。寻找青年时期的前驱糖尿病对于预防2型糖尿病和长期合并症非常重要。

原始出处:

S. S. CasagrandeA. MenkeB. Linderet al. Cardiovascular risk factors in adolescents with prediabetes

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    2018-11-01 misszhang

    谢谢MedSci提供最新的资讯

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