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Arthritis Rheumatol:抗磷脂综合征的流行病学

2019-04-10 xiangting MedSci原创

每100,000人每年约有2人发生APS。估算患病率为每100,000人50例。总死亡率与一般人群没有差异。

这项研究旨在估算抗磷脂综合征(APS)的发病率、患病率和死亡率。

根据全面的个人病历审查在地理定义明确的人群中确定了一个2000-2015年偶发性APS患者初始队列。所有病例均符合2006年悉尼APS标准(主要定义)或由医生共识患有APS(次要定义)。在一个集中式实验室中检测狼疮抗凝物、IgM和IgG aCL以及抗β2糖蛋白-1抗体。根据2010年美国白人人群的年龄和性别对发病率进行调整。假设没有与APS相关的死亡率升高并且进出该区域的迁移与疾病状态无关,从发病率估算患病率。

在2000-2015年,根据悉尼标准确定了33例偶发性APS(平均年龄54.2岁,55%为女性; 97%为高加索人)。年龄≥18岁每100,000人APS的年发病率为2.1(95%可信区间[CI]:1.4-2.8)。男女的发病率相似。APS的估算患病率为每100,000人50例(95%CI:42-58),男女相似。6名患者(18%)同时被诊断为系统性红斑狼疮。最常见的临床表现是深静脉血栓形成。APS患者的总死亡率与一般人群无显著差异(标准化死亡率:1.61; 95%CI:0.74-3.05)。

每100,000人每年约有2人发生APS。估算患病率为每100,000人50例。总死亡率与一般人群没有差异。

原始出处:

Ali Duarte‐García. The Epidemiology of Antiphospholipid Syndrome. A Population‐Based Study. Arthritis Rheumatol. 08 April 2019.

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    2019-04-12 zhaojie88
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    2019-04-12 xugumin
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