J Cell Biol：驱动癌症转移的新机制

2015-03-05 佚名生物谷

根据蒙特利尔神经学研究所和麦吉尔大学研究员完成的一项新的研究发现：一种在人类细胞中普遍存在的蛋白质可能是一个重要开关，能激活癌细胞转移。到目前为止，这一重要的发现在很大程度上被忽略。这一蛋白质作用的发现，显著扩展了我们对上皮癌如乳腺癌和肺癌的认识。该研究发现了DENND2B蛋白质的功能。在儿童发育过程中，DENND2B可能对细胞的正常迁移有作用。在成人中，细胞迁移大大降低，但在癌症的情况下

根据蒙特利尔神经学研究所和麦吉尔大学研究员完成的一项新的研究发现：一种在人类细胞中普遍存在的蛋白质可能是一个重要开关，能激活癌细胞转移。到目前为止，这一重要的发现在很大程度上被忽略。这一蛋白质作用的发现，显著扩展了我们对上皮癌如乳腺癌和肺癌的认识。

该研究发现了DENND2B蛋白质的功能。在儿童发育过程中，DENND2B可能对细胞的正常迁移有作用。在成人中，细胞迁移大大降低，但在癌症的情况下，发生了不必要的细胞迁移，能促进肿瘤细胞转移到新部位。

DENND2B激活另一种蛋白质Rab13，Rab13是促进细胞迁移酶。到现在为止，我们还不知道Rab13如何激活启动细胞的迁移。

研究人员发现Rab13在许多类型的癌症特别是经常转移至脑部的上皮癌中异常高程度的表达。重要的是要弄清楚Rab13在细胞中哪里被开启，搞清楚它在哪里激活对于它是如何发挥作用是很重要的。研究看到DENND2B蛋白在细胞的前缘激活Rab13。

主要研究者McPherson博士认为Rab13或许是未来研究癌症疗法的重点。研究者将含有高水平Rab13蛋白质的乳腺癌细胞以及Rab13被人为地剔除的侵袭性乳腺癌细胞注入到小鼠体内。

在具有较低Rab13水平的乳腺癌细胞情况下，鼠体内癌症压根不生长或只能形成一个更小的肿瘤。此外，所形成的更小的肿瘤没有转移到其他组织。在这项研究之前，没有人认为， Rab13在癌症中的重要作用，McPherson博士补充说，新的研究发现将推动临床试验的开展.

原始出处

M. S. Ioannou, E. S. Bell, M. Girard, M. Chaineau, J. N. R. Hamlin, M. Daubaras, A. Monast, M. Park, L. Hodgson, P. S. McPherson.DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.J Cell Biol.2015

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#插入话题

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2015-11-16 维他命

#CEL#

74 0
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2015-06-22 12498ebem31暂无昵称

#Biol#

91 0
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2015-07-22 sunylz

#Bio#

51 0
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2015-05-16 ljjj1053

很不错学习了

175 0
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2015-11-10 zhaozhouchifen

#Cell#

0 0
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2015-03-07 xirongguo

#癌症转移#

111 0
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2015-03-05 lovetcm

国内朋友也可以去研究看看

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