【衡道丨干货】WHO图注英文学习手帐（未分类的混合性生殖细胞-性索-间质肿瘤）

衡道病理特邀撰稿作者翻译了WHO部分图⽚的图注，并用手帐的⽅式进行中英对照，且通过不同颜色的划线将晦涩难懂的英文单词与中⽂翻译同时标注，希望对专业英文的学习有所帮助。上一期分享了性腺母细胞瘤，本期将带来未分类的混合性生殖细胞-性索-间质肿瘤。由于本篇目的以英文学习为主，篇幅有限，故未对各个疾病进行详细阐述。全部图片均来自WHO，若有不恰当之处，还请评论区指正。

WHO图注英文学习手帐

Mixed germ cell-sex cord-stromal tumour,nclassified

混合性生殖细胞-性索-间质瘤，未分类

Definition

Mixed germ cell-sex cord-stromal tumour, unclassified, is a neoplasm composed of germ cells and sex cord cells occurring in phenotypically and genetically female patients that does not have the distinctive appearance of a gonadoblastoma.

定义

混合性生殖细胞-性索间质瘤肿瘤，未分类，是由生殖细胞和性索细胞组成的肿瘤，发生在表型和遗传上的女性患者中，没有性腺母细胞瘤的独特外观。

ICD-O coding

8594/1 Mixed germ cell-sex cord-stromal tumour NOS

ICD-O编码

8594/1 混合性生殖细胞-性索-间质肿瘤NOS

Histopathology

组织病理学

Microscopically,these tumours show a variable and haphazard admixture of germ cells and sex cord cells. The germ cells are found singly or in small clusters and are large, with pleomorphic nuclei and ample, often clear and PAS-positive cytoplasm, resem-bling dysgerminomatumour cells.

显微镜下，这些肿瘤显示出生殖细胞和性索细胞的不同程度的混合。生殖细胞呈单个或小簇状，体积大，细胞核多形性，细胞质丰富，通常是透明的，PAS阳性，类似于无性细胞瘤。

Sex cord cells may form cords or trabeculae, hollow or solid tubules (sometimes resembling sexcord tumours with annular tubules), or cysts, or they may grow diffusely. lmmunohistochemically, the sex cord elements are typically positive for inhibin. The germ cells resemble dysgerminoma cellsand are immunoreactive for PLAP, OCT4, and KIT .

性索细胞可形成索索状或小梁状、空心或实性小管(有时类似于(有时类似于伴有环状小管的性索肿瘤有性索肿瘤的环状小管)或囊肿，也可呈弥漫性生长。免疫组织化学上，性索细胞通常inhibin呈典型阳性。生殖细胞类似于无性生殖细胞瘤，PLAP、OCT4和KIT阳性。

Essential and desirable diagnostic criteria

Essential: an ovarian tumour consisting of an irregularadmixture of dysgerminoma-like germ cells and sex cord cells not exhibiting the distinctive appearance of a gonadoblastoma.

必要和理想的诊断标准:

必要的：一种卵巢肿瘤，由无性细胞瘤样的生殖细胞和性索细胞的不规则混合而成。不具有性腺母细胞瘤的独特外观。

Mixed oerm cell-sex cord-stromal tumour, unclassified.

混合性生殖细胞-性索间质肿瘤，未分类

A showing an admixture of germ cells and sex cord cells (top lelt and right).Sex cord cells also grow in clustered hollow or solid tubules (centre and bottom). 

A 显示混合性生殖细胞和性索成分。(顶部左侧和右侧)。性索细胞也生长成簇状的中空或实心小管中(中央和底部)。

B Mixed germ cell-sex cord-stromal tumour showing an admixture of germ cell and sex cord components arranged in a haphazard fashion. The germ cells are large, with pleomorphic nuclei and ample cytoplasm, resembling dysgerminoma tumour cells. The smaller sex cord cells surround the germ cells, forming cords or trabeculae.

混合性生殖细胞-性索间质肿瘤，显示生殖细胞和性索成分以随意方式混合排列。生殖细胞大，细胞核多形性，细胞质丰富，类似于无性细胞瘤。较小的性索细胞环绕在生殖细胞周围，形成索状或小梁状结构。