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J Matern Fetal Neonatal Med:口服扑热息痛VS口服布洛芬治疗早产儿动脉导管未闭的疗效和安全性

2020-10-05 MedSci原创 MedSci原创

本研究旨在评价口服扑热息痛与口服布洛芬治疗早产儿动脉导管未闭(hsPDA)的疗效和安全性,研究结果已在线发表于J Matern Fetal Neonatal Med。

本研究旨在评价口服扑热息痛与口服布洛芬治疗早产儿动脉导管未闭(hsPDA)的疗效和安全性,研究结果已在线发表于J Matern Fetal Neonatal Med。

研究人员对60名胎龄≤34周、产后2~7d以及hsPDA彩色多普勒超声心动图证实的早产儿进行干预性随机病例对照研究。将新生儿随机分为两组:30例口服布洛芬和30例口服对乙酰氨基酚。如果导管关闭失败,则给予布洛芬或扑热息痛第二个疗程。对纳入的新生儿进行详细的病史、临床检查、实验室检查,包括全血细胞计数、肾脏、肝功能检查和超声心动图评估。

 

结果显示,口服扑热息痛与布洛芬同样有效,一个疗程即可闭合动脉导管未闭(PDA)(P>.05)。此外,在需要第二疗程治疗的新生儿中,与布洛芬组相比,口服扑热息痛优于布洛芬,左肺动脉舒张末期流速(0.35 ± 0.09 vs. 0. 19 ± 0.06,p = .014),右心室收缩压(40.50 ± 12.91 vs. 20.50 ± 0.58,p = .016)和左心房与主动脉根比值(1.23 ± 0.14 vs. 1.07 ± 0.04,p = .046)显著下降。此外,在第二个疗程治疗后,与布洛芬组相比,扑热息痛组治疗前和治疗后PDA大小的平均差异显著高于布洛芬组(1.07±0.32 vs. 0.73±0.38,p = .024)。口服扑热息痛与布洛芬在非手术导管闭合率方面相当[28(93.3%)vs. 24(80%),p = .591]。此外,在胃肠道穿孔或出血、坏死性肠炎、支气管肺发育不良、静脉内出血、血小板减少、肝或肾功能障碍方面,口服扑热息痛与口服布洛芬一样安全。

 

综上所述,该研究结果表明,口服扑热息痛是治疗早产儿PDA有效且耐受性好的一线药物治疗。

 

原始出处:

 

Rania A El-FarrashMohammed S El Shimy, et al., Efficacy and safety of oral paracetamol versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants: a randomized controlled trial. J Matern Fetal Neonatal Med. 2019 Nov;32(21):3647-3654. doi: 10.1080/14767058.2018.1470235. 

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    2021-03-05 zhangxiang

    学习了,好

    0

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    2021-01-23 liye789132251
  5. [GetPortalCommentsPageByObjectIdResponse(id=1720969, encodeId=1e8e1e2096935, content=<a href='/topic/show?id=634ee040179' target=_blank style='color:#2F92EE;'>#疗效和安全性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70401, encryptionId=634ee040179, topicName=疗效和安全性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=16ef32982072, createdName=经常头晕, createdTime=Thu Jun 03 02:44:46 CST 2021, time=2021-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715982, encodeId=26941e1598217, content=<a href='/topic/show?id=3f5f54610fe' target=_blank style='color:#2F92EE;'>#扑热息痛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54610, encryptionId=3f5f54610fe, topicName=扑热息痛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=810132108698, createdName=shenxlcyp, createdTime=Mon Dec 14 16:44:46 CST 2020, time=2020-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945725, encodeId=39fd945e25a2, content=学习了,好, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201117/a59b28b63198490ea85b1e5b3d13c2bf/1b1e0d03ca22467d8120443ebbc24c04.jpg, createdBy=35d22207591, createdName=zhangxiang, createdTime=Fri Mar 05 14:15:47 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1884704, encodeId=86371884e0403, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jan 23 06:44:46 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1985290, encodeId=4058198529089, content=<a href='/topic/show?id=18f612646a4' target=_blank style='color:#2F92EE;'>#Neon#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12646, encryptionId=18f612646a4, topicName=Neon)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIOca9icPByKxo3ZRUrvuibf7tWt7EScQ1NEiaKy4NCUctSU2jDjOayLicDIaicwUxaQhJ1SZKdEevgjRg/132, createdBy=4f272500131, createdName=若水123, createdTime=Wed Jul 21 15:44:46 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466101, encodeId=7e851466101d3, content=<a href='/topic/show?id=217c292009' target=_blank style='color:#2F92EE;'>#ATA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2920, encryptionId=217c292009, topicName=ATA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387a6772119, createdName=bbjsj_1981, createdTime=Tue Oct 06 16:44:46 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522281, encodeId=060415222811f, content=<a href='/topic/show?id=ed183323e02' target=_blank style='color:#2F92EE;'>#动脉导管未闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33237, encryptionId=ed183323e02, topicName=动脉导管未闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40e811444670, createdName=shizhenshan, createdTime=Tue Oct 06 16:44:46 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610741, encodeId=5a131610e41bf, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Oct 06 16:44:46 CST 2020, time=2020-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032670, encodeId=437a10326e0c6, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Mon Oct 05 04:44:46 CST 2020, time=2020-10-05, status=1, ipAttribution=)]
    2021-07-21 若水123
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    2020-10-06 bbjsj_1981
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    2020-10-05 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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