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JCO:老年乳腺癌患者肿瘤治疗相关的认知功能结局

2018-10-31 MedSci MedSci原创

JCO近期发表了一篇文章,研究治疗及年龄相关因素对老年乳腺癌患者认知功能的影响。

JCO近期发表了一篇文章,研究治疗及年龄相关因素对老年乳腺癌患者认知功能的影响。

在2010年8月至2015年12月期间,研究纳入新诊断的非转移性乳腺癌患者(n = 344)和无癌症的对照研究对象(n = 347),入组标准年龄为60岁及以上,无痴呆或神经系统疾病。通过调查,癌症治疗认知功能自我评估,以及针对注意力,处理速度和执行功能(APE)和学习记忆(LM)的神经心理学测试分析认知功能。研究结果表明,肿瘤组和对照组研究对象年龄在60至98岁之间,受过良好教育,并具有相似的基线认知得分。治疗与认知评分有关,接受化疗的肿瘤患者APE评分较差,且在12个月时开始激素治疗的患者LM评分比其他组低。年龄增加与认知基线评分降低相关,情感脆弱与基线APE和自我报告功能下降相关。

文章最后认为,乳腺癌系统治疗和衰老与老年乳腺癌患者的认知功能评分降低相关。这些研究结果有助于患者的治疗及护理决策。

原始出处:

Jeanne S. Mandelblatt, Brent J. Small, et al. Cancer-Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study. JCO. October 2018 doi: 10.1200/JCO.18.00140

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    2018-11-18 lidong40
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