JACC：血小板在外周动脉疾病发生中的机制研究

2018-01-04 MedSci MedSci原创

外周动脉疾病（PAD）是动脉粥样硬化血栓形成的一种弥漫性病变，对患者心血管有潜在风险。血小板虽然是动脉粥样硬化血栓形成的关键因子，但其在PAD中的发病机制尚未阐明。本研究有症状的PAD患者和正常对照进行血小板活性、mRNA和效应器活性的检测。血小板RNA测序结果显示粒细胞相关蛋白(MRP)-14 mRNA在PAD患者中有明显的上调，循环中火化的血小板富含MRP-14蛋白，它可以促进黏附介质（P-选

外周动脉疾病（PAD）是动脉粥样硬化血栓形成的一种弥漫性病变，对患者心血管有潜在风险。血小板虽然是动脉粥样硬化血栓形成的关键因子，但其在PAD中的发病机制尚未阐明。本研究对有症状的PAD患者和正常对照进行血小板活性、mRNA和效应器活性的检测。血小板RNA测序结果显示粒细胞相关蛋白(MRP)-14 mRNA在PAD患者中有明显的上调，循环中活化的血小板富含MRP-14蛋白，它可以促进黏附介质（P-选择素）的表达，从而促进单核细胞-血小板聚集。血小板驱动的MRP-14被输送至单核细胞，以促进PAD关键损伤标志物的表达，并增加其定向运动。循环血液MRP-14的增高不仅与PAD的发生相关，也与其疾病的严重程度相关。研究结果显示，外周动脉疾病的血小板活性明显增高，并揭示了免疫调节效应分子MRP-14通过调节单核细胞活性在PAD中的作用。原始出处：Rebecca D et al.Platelet-Derived MRP-14 Induces Monocyte Activation in Patients With Symptomatic Peripheral Artery Disease.JAC

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2018-01-29 hbwxf

#机制研究#

73 0
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2018-09-09 hbwxf

#JACC#

107 0
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2018-01-06 Jackie Li

学习

143 0
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2018-01-06 12498568m50暂无昵称

#ACC#

134 0
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2018-01-06 wujh_7312825

#外周动脉#

137 0
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2018-01-04 139****5926

好好文章学习了

135 0
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2018-01-04 1e0e5697m83(暂无匿称)

henhao

154 0

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