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J Gastroenterology: 肝FATP5表达与NAFLD患者的肝病炎症进展和肝脂肪流失有关

2019-11-30 不详 MedSci原创

非酒精性脂肪肝疾病(NAFLD)和非酒精性脂肪性肝炎(NASH)的特征是肝脂肪过多。但是,在从NASH到肝硬化的过程中,经常会丢失肝脂肪。因此,本项研究的目的是阐明NASH进展期间肝脏脂肪流失的潜在机制。

背景
非酒精性脂肪肝疾病(NAFLD)和非酒精性脂肪性肝炎(NASH)的特征是肝脂肪过多。但是,在从NASH到肝硬化的过程中,经常会丢失肝脂肪。因此,本项研究的目的是阐明NASH进展期间肝脏脂肪流失的潜在机制。

方法
研究人员收集了2011年11月至2016年3月之间在东京大学医院146例未接受任何糖尿病或血脂异常药物治疗的NAFLD患者和14例隐源性肝硬化患者的肝活检数据。其中,有70例患者在一夜禁食后进行了肝活检,而90例患者在口服葡萄糖耐量试验后5小时进行了活检。基于NAFLD活性评分,检查了编码几种脂肪酸代谢相关因子的基因的表达差异,并将其与肝组织学变化进行比较。

结果
与游离脂肪酸摄入相关的脂肪酸转运蛋白5(FATP5)的水平与组织学进展的特征(包括膨胀和纤维化)显着呈负相关。免疫组织化学分析证实了这一点。在患有严重纤维化的NASH和隐源性肝硬化之间,编码脂肪酸代谢相关蛋白的基因的转录水平可比。此外,一项前瞻性队列研究表明,FATP5低表达是肝脂肪流失的最重要危险因素。

结论
NAFLD中肝FATP5表达的减少与组织学进展有关,并且可能与NASH进展为肝硬化期间的肝脂肪减少有关。

原始出处:

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    2020-08-15 许安
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    2020-07-14 lvygwyt2781
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    2019-12-02 listen320
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