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J Periodontol:慢性牙周病、牙周病原菌定植和胃癌前病变的风险增加

2017-11-11 MedSci MedSci原创

本研究评估了牙周病原菌定植与临床上癌前病变(PLGC)发展为胃癌的潜在风险之间的关系。

本研究评估了牙周病原菌定植与临床上癌前病变(PLGC)发展为胃癌的潜在风险之间的关系。

方法:纳入35例初发PLGC患者和70例年龄相匹配的无PLGC患者。进行全口腔内检查以评估牙周状况。通过收集唾液和菌斑样品以评估牙龈卟啉单胞菌,齿垢密螺旋体,福赛斯坦纳菌和伴放线放线杆菌,检测唾液和牙斑中的口腔微生物多样性。

结果:与对照组相比,PLGC患者在探诊时出血率较高(31.5% vs 22.4%,P <0.05),齿垢密螺旋体(P <0.01)和伴放线放线杆菌(P <0.01) ,唾液中细菌多样性较低(P <0.01)。包含所有关键社会人口学特征,口腔健康行为因素和牙周评估结果组成的最终多元逻辑回归模型揭示了牙周病原体,特别是齿垢密螺旋体,福赛斯坦纳菌和伴放线放线杆菌的增殖,牙菌斑中的细菌多样性降低,不定期使用牙齿清洁剂是PLGC风险增加的重要预测因子(P = 0.022)。

结论:本研究提供了新的证据,表明牙周病原体负荷和口腔细菌多样性是造成癌前病变的潜在风险增加的重要因素。

原始出处:

Jinghua Sun, et al. Chronic Periodontal Disease, Periodontal Pathogen Colonization, and Increased Risk of Precancerous Gastric Lesions. Journal of Periodontology. 2017 November. doi: 10.1902/jop.2017.160829

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    2018-01-28 feather89
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  5. 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  6. 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    2017-11-11 xiaotao112411

    学习学习学习

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  7. 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    2017-11-11 xiaotao112411

    学习学习学习

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  8. 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  9. 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    2017-11-11 xiaotao112411

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