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MedSci专访李进:分子靶向治疗大肠癌进展

2015-08-17 MedSci MedSci原创

由梅斯医学主办的2015精准医疗研讨会于8月13-14号上海好望角酒店举行,本届将以精准医疗为切入点,将基础研究与临床应用相结合,邀请国内外顶尖的专家,针对基因组学、生物信息、在癌症,神经,心血管等疾病领域中精准医疗的研究进展等议题进行讨论。MedSci现场采访复旦大学附属肿瘤医院肿瘤内科李进教授 。MedSci:李教授,您好,感谢您接收medsci的采访。大肠癌是常见的恶性肿瘤,能否跟我们分享一



由梅斯医学举办的2015精准医疗研讨会于8月13-14号上海好望角酒店举行,本届以精准医疗为切入点,将基础研究与临床应用相结合,邀请国内外顶尖的专家,针对基因组学、生物信息、在癌症,神经,心血管等疾病领域中精准医疗的研究进展等议题进行讨论。

MedSci现场采访复旦大学附属肿瘤医院肿瘤内科李进教授 。

MedSci:李教授,您好,感谢您接受medsci的采访。大肠癌是常见的恶性肿瘤,能否跟我们分享一下大肠癌的分子靶向治疗大肠癌有什么样的进展?临床使用情况如何?

李教授:大肠癌是常见的恶性肿瘤疾病,具有很强的危害性。大肠癌的治疗方法有很多,其中大肠癌分子靶向治疗是近些年比较兴起的治疗方法。

从2001年格列卫药物应用到临床之后,大肠癌的治疗才真正的进入到了分子靶向细胞阶段。在大肠癌治疗分子靶向药物中,有几个药物不得不提:首先是抗血管形成的药物。过去我们不知道肿瘤的生长跟血管的生成有密切关系。自从folkman提出肿瘤生长依赖于血管新生的概念,我们才初步了解到肿瘤区域的血管生长有密切关系,在某种意义上,控制血管的生长就能控制肿瘤的生长。之后,在大肠癌的临床研究中,有很多抗血管形成药物。例如血管内皮生长因子(VEGF)的贝伐单抗,单克隆抗体,靶向药物,从所获得的证据来看,抗血管形成的药物对大肠癌有好的疗效。另一方面,肿瘤细胞表面有各种各样跟生长有关的分子,也有相关的药物VEGF-R,单克隆抗体,靶向药物,目前比较成熟的是西妥昔单抗,尤其是在结直肠癌二、三线治疗中单药或联合化疗的疗效获得证明。我们相信,在不久的未来,靶向治疗有可能成为大肠癌的常规治疗方案,并将使更多的患者受益。

MedSci:在分子靶向治疗大肠癌中,还有哪些困难急需解决?

李教授:分子靶向药物能够延长大肠癌患者的生存期,但延长的时间很有限,最长的生存期也只有29-30个月左右,如何让能病人生存的更久,能够代瘤生存,这是我们需要攻克的难题。即使用了靶向分子药物,肿瘤也会发生先天性或者后天性耐药,而且肿瘤具有高度异质性,一个肿瘤组织中不是单纯的一种细胞,包括很多不同突变的细胞,细胞的亚群,用同种药物很难同时治疗,所以我们希望能够研究更多的药物,延长患者生存期,降低社会成本。最近刚刚研究成功的瑞戈非尼可用于二线化疗失败后的患者,并在LANCET ONCOL上发表我们的研究报告。我们团队也正在开展小分子靶向药物和单克隆抗体在大肠癌应用的研究。

MedSci:您长期工作在科研第一线,在肿瘤领域中取得很高的成就,在肿瘤领域中,您在临床研究方面,有哪些心得是可以分享给一些年轻的医生呢?或者对青年医生做科研,有什么鼓励?

李教授:做研究就像是厨师,做蛋糕就好好做蛋糕,蒸馒头就好好蒸馒头,所以临床研究工作者不要总是养细胞,养老鼠,临床医生一定要注重临床,要围绕病人,提高治疗病人的能力,解决好临床上的问题。在做科研的时候,不要眼高手低,切记好高骛远。要做好科研需要长时间的积累,不管你做的是小课题还是大课题,只要能改变现有的临床实践,就是好课题,好研究,就能发高期刊。所以希望我们临床科研工作者一定要注重临床,培养临床能力,其次才是科研能力。

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    2015-08-18 zhangjian2013

    学习下

    0

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    2015-08-18 Jianghuiqin

    赞!李进老师很有才~

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1703176, encodeId=687c1e031766f, content=<a href='/topic/show?id=dba720e31b7' target=_blank style='color:#2F92EE;'>#专访#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20731, encryptionId=dba720e31b7, topicName=专访)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=070a30497323, createdName=flyingeagle87, createdTime=Thu Jan 21 21:59:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986931, encodeId=6ce3198693166, content=<a href='/topic/show?id=77dd31e07c0' target=_blank style='color:#2F92EE;'>#分子靶向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31707, encryptionId=77dd31e07c0, topicName=分子靶向)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Thu Apr 14 22:59:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606571, encodeId=b13e16065e17e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Aug 19 04:59:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35786, encodeId=890635e86ad, content=学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/HZB3B60meJ5WPRXjCibscwOyCnDk5mp86eON0v17Q66c0vp87QyAlflMiczuJlLnTrFtsBg3tgWPPqFBoQZjT0ww/132, createdBy=c54677613, createdName=zhangjian2013, createdTime=Tue Aug 18 00:10:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35777, encodeId=088935e7711, content=赞!李进老师很有才~, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Tue Aug 18 00:01:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35739, encodeId=f73135e39e7, content=好好学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b159816, createdName=shneye, createdTime=Mon Aug 17 16:52:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35733, encodeId=cef435e33d4, content=讲的很好 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:13:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35732, encodeId=480635e320d, content=李老师讲的不错 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:11:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35731, encodeId=8f8135e3183, content=李老师讲的不错 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:10:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2015-08-17 shneye

    好好学习下

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1703176, encodeId=687c1e031766f, content=<a href='/topic/show?id=dba720e31b7' target=_blank style='color:#2F92EE;'>#专访#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20731, encryptionId=dba720e31b7, topicName=专访)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=070a30497323, createdName=flyingeagle87, createdTime=Thu Jan 21 21:59:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986931, encodeId=6ce3198693166, content=<a href='/topic/show?id=77dd31e07c0' target=_blank style='color:#2F92EE;'>#分子靶向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31707, encryptionId=77dd31e07c0, topicName=分子靶向)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Thu Apr 14 22:59:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606571, encodeId=b13e16065e17e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Aug 19 04:59:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35786, encodeId=890635e86ad, content=学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/HZB3B60meJ5WPRXjCibscwOyCnDk5mp86eON0v17Q66c0vp87QyAlflMiczuJlLnTrFtsBg3tgWPPqFBoQZjT0ww/132, createdBy=c54677613, createdName=zhangjian2013, createdTime=Tue Aug 18 00:10:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35777, encodeId=088935e7711, content=赞!李进老师很有才~, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Tue Aug 18 00:01:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35739, encodeId=f73135e39e7, content=好好学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b159816, createdName=shneye, createdTime=Mon Aug 17 16:52:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35733, encodeId=cef435e33d4, content=讲的很好 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:13:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35732, encodeId=480635e320d, content=李老师讲的不错 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:11:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35731, encodeId=8f8135e3183, content=李老师讲的不错 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:10:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2015-08-17 Numb

    讲的很好 很有帮助

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1703176, encodeId=687c1e031766f, content=<a href='/topic/show?id=dba720e31b7' target=_blank style='color:#2F92EE;'>#专访#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20731, encryptionId=dba720e31b7, topicName=专访)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=070a30497323, createdName=flyingeagle87, createdTime=Thu Jan 21 21:59:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986931, encodeId=6ce3198693166, content=<a href='/topic/show?id=77dd31e07c0' target=_blank style='color:#2F92EE;'>#分子靶向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31707, encryptionId=77dd31e07c0, topicName=分子靶向)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Thu Apr 14 22:59:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606571, encodeId=b13e16065e17e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Aug 19 04:59:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35786, encodeId=890635e86ad, content=学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/HZB3B60meJ5WPRXjCibscwOyCnDk5mp86eON0v17Q66c0vp87QyAlflMiczuJlLnTrFtsBg3tgWPPqFBoQZjT0ww/132, createdBy=c54677613, createdName=zhangjian2013, createdTime=Tue Aug 18 00:10:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35777, encodeId=088935e7711, content=赞!李进老师很有才~, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Tue Aug 18 00:01:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35739, encodeId=f73135e39e7, content=好好学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b159816, createdName=shneye, createdTime=Mon Aug 17 16:52:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35733, encodeId=cef435e33d4, content=讲的很好 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:13:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35732, encodeId=480635e320d, content=李老师讲的不错 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:11:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35731, encodeId=8f8135e3183, content=李老师讲的不错 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:10:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2015-08-17 Numb

    李老师讲的不错 很有帮助

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1703176, encodeId=687c1e031766f, content=<a href='/topic/show?id=dba720e31b7' target=_blank style='color:#2F92EE;'>#专访#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20731, encryptionId=dba720e31b7, topicName=专访)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=070a30497323, createdName=flyingeagle87, createdTime=Thu Jan 21 21:59:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986931, encodeId=6ce3198693166, content=<a href='/topic/show?id=77dd31e07c0' target=_blank style='color:#2F92EE;'>#分子靶向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31707, encryptionId=77dd31e07c0, topicName=分子靶向)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f00658, createdName=yyanpro@21cn.c, createdTime=Thu Apr 14 22:59:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606571, encodeId=b13e16065e17e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Aug 19 04:59:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35786, encodeId=890635e86ad, content=学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=158, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/HZB3B60meJ5WPRXjCibscwOyCnDk5mp86eON0v17Q66c0vp87QyAlflMiczuJlLnTrFtsBg3tgWPPqFBoQZjT0ww/132, createdBy=c54677613, createdName=zhangjian2013, createdTime=Tue Aug 18 00:10:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35777, encodeId=088935e7711, content=赞!李进老师很有才~, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Tue Aug 18 00:01:00 CST 2015, time=2015-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35739, encodeId=f73135e39e7, content=好好学习下, beContent=null, objectType=article, channel=null, level=null, likeNumber=188, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b159816, createdName=shneye, createdTime=Mon Aug 17 16:52:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35733, encodeId=cef435e33d4, content=讲的很好 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:13:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35732, encodeId=480635e320d, content=李老师讲的不错 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:11:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35731, encodeId=8f8135e3183, content=李老师讲的不错 很有帮助, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cache2.medsci.cn/upload/content/day_150818/201508181329556525.jpg, createdBy=f9191625396, createdName=Numb, createdTime=Mon Aug 17 14:10:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2015-08-17 Numb

    李老师讲的不错 很有帮助

    0

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大肠癌是一种十分常见的胃肠道癌症,近些年来,大肠癌的死亡率在中国位于癌症致死率的第三位,而且其发病率呈现逐年上升趋势。目前,越来越多的证据证明,肿瘤起始细胞不仅仅存在于大脑,乳腺,前列腺及胰腺等实体瘤中,这些细胞也存在于大肠癌中。实体瘤中的细胞有一种复杂的等级制度,其中,肿瘤起始细胞是一小群具有正常干细胞特性的肿瘤细胞,这些细胞可以自我更新,具有分化多潜能性和强大的致癌性。最近,有报道称,肿瘤起始

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