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PLoS One:佛罗里达州18岁以上成人糖尿病前期和糖尿病发生和预测因子

2016-01-04 phylis 译 MedSci原创

背景:糖尿病前期和糖尿病的患者形成大血管并发症的风险增加,包括心脏病和卒中;这是导致全球死亡的主要原因。本研究的目的是评估糖尿病前期和糖尿病的患病率,并探讨佛罗里达州18年以上成人中的预测因子。方法:数据从佛罗里达州的行为危险因素监测系统(BRFSS)获得,时间为2013年1月至12月。调查研究由Stata 13.1中SVYSEY设计。描述性分析,评估糖尿病前期和糖尿病患者的发生率。应用多元回归模

背景:糖尿病及糖尿病前期患者会增加大血管并发症的风险,包括心脏病和卒中;这是全球死亡的主要原因。本研究的目的是评估糖尿病前期和糖尿病的患病率,并探讨佛罗里达州成人的预测因子。

方法:数据从佛罗里达州的行为危险因素监测系统(BRFSS)获得,时间为2013年1月至12月。调查研究由Stata 13.1中SVYSEY设计。描述性分析,评估糖尿病前期和糖尿病患者的发生率。应用多元回归模型调查糖尿病前期和糖尿病患者的预测因子。应用Fagerland、Hosmer、Bofin和Hosmer-Lemeshow's多项式拟合优度检验模型的拟合优度检验。

结果:研究过程中,约有2983(7.3%)名和5189(12.1%)名的成年人分别诊断为糖尿病前期和糖尿病。超过一半的受试者为白人、已婚或者年龄超过45岁;36.4%受试者体育锻炼较少,体重超重(36.4%)或肥胖(26.4%)、高血压(34.6%)、高胆固醇(40.3%)、26%关节炎。基于最终的多变量多维度模型,只有超重(RRR= 1.85,95% CI = 1.41,2.42)、肥胖(RRR = 3.41,95% CI = 2.61,4.45)、高血压(RRR = 1.69,95% CI = 1.33,2.15)、高胆固醇血症(RRR= 1.94,95% CI = 1.55,2.43)和关节炎(RRR = 1.24,95% CI = 1,1.55)与糖尿病前期显著相关。然而,更多的预测因子与糖尿病相关,并且相关程度比与糖尿病前期更高。例如,糖尿病和肥胖之间的相关的的相对风险比(RRR = 2,95% CI = 1.55,2.57),或肥胖(RRR = 4.04,95% CI = 3.22,5.07)、高血压(RRR = 2.66,95% CI = 2.08,3.41)、高胆固醇血症(RRR = 1.98,95% CI = 1.61,2.45)和关节炎(RRR = 1.28,95% CI = 1.04,1.58)均高于糖尿病前期的相关程度。

此外,一些变量,如年龄、收入水平、性别、身体锻炼水平与糖尿病显著相关,而不是与糖尿病前期相关。随着年龄增加,低收入水平,男性和身体锻炼较少与糖尿病风险增加相关。不足的体育锻炼与糖尿病或糖尿病前期发生风险增加没有显著相关。

结论:佛罗里达州18岁以上的成人糖尿病状态水平不同,预测因子相关性也不同。监测糖尿病前期和糖尿病高风险人群,以帮助指导健康规划决策和资源分配。

原文出处:

Okwechime IO1, Roberson S2, Odoi A1. Prevalence and Predictors of Pre-Diabetes and Diabetes among Adults 18 Years or Older in Florida: A Multinomial Logistic Modeling Approach. PLoS One. 2015 Dec 29.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1789765, encodeId=aab61e8976528, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Mar 26 04:55:00 CST 2016, time=2016-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56537, encodeId=0cd05653ec6, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Jan 13 07:51:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52593, encodeId=c96b52593a9, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:57:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52592, encodeId=d21852592b0, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:56:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310615, encodeId=2a87131061567, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Wed Jan 06 12:55:00 CST 2016, time=2016-01-06, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1789765, encodeId=aab61e8976528, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Mar 26 04:55:00 CST 2016, time=2016-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56537, encodeId=0cd05653ec6, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Jan 13 07:51:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52593, encodeId=c96b52593a9, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:57:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52592, encodeId=d21852592b0, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:56:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310615, encodeId=2a87131061567, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Wed Jan 06 12:55:00 CST 2016, time=2016-01-06, status=1, ipAttribution=)]
    2016-01-13 qingfengqishi5

    收藏了

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  3. [GetPortalCommentsPageByObjectIdResponse(id=1789765, encodeId=aab61e8976528, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Mar 26 04:55:00 CST 2016, time=2016-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56537, encodeId=0cd05653ec6, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Jan 13 07:51:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52593, encodeId=c96b52593a9, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:57:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52592, encodeId=d21852592b0, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:56:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310615, encodeId=2a87131061567, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Wed Jan 06 12:55:00 CST 2016, time=2016-01-06, status=1, ipAttribution=)]
    2016-01-06 xyfg98

    赞一个

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1789765, encodeId=aab61e8976528, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Mar 26 04:55:00 CST 2016, time=2016-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56537, encodeId=0cd05653ec6, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Jan 13 07:51:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52593, encodeId=c96b52593a9, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:57:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52592, encodeId=d21852592b0, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:56:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310615, encodeId=2a87131061567, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Wed Jan 06 12:55:00 CST 2016, time=2016-01-06, status=1, ipAttribution=)]
    2016-01-06 xyfg98

    好文章

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1789765, encodeId=aab61e8976528, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Mar 26 04:55:00 CST 2016, time=2016-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56537, encodeId=0cd05653ec6, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Jan 13 07:51:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52593, encodeId=c96b52593a9, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:57:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=52592, encodeId=d21852592b0, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Wed Jan 06 21:56:00 CST 2016, time=2016-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310615, encodeId=2a87131061567, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Wed Jan 06 12:55:00 CST 2016, time=2016-01-06, status=1, ipAttribution=)]

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糖尿病是当前威胁全球人类健康最重要的慢性非传染性疾病之一,多项全国多中心流行病学研究已证实我国成人糖尿病患病率高达 9% 以上,糖尿病可能比我们预想的发展更快,已经成为我国重大公共卫生问题。大量流行病学研究显示,糖尿病是心血管疾病的独立危险因素,糖尿病患者是心血管疾病的高危人群。在糖尿病诊断后的 20 年,糖尿病血管并发症将相继发生,治疗费用占全

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