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Lancet Diab & Endo:两成亚洲成年2型糖尿病为早发型糖尿病

2014-08-06 伊文 中华医学会糖尿病学分会

中国香港中文大学Juliana C N Chan等公布的JADE项目表明,在亚洲成年2型糖尿病患者中,1/5为早发(40岁以前发病)型糖尿病。与迟发型2型糖尿病患者相比,早发型2型糖尿病患者的代谢危险因素控制较差,接受有利于器官保护的药物治疗者较少。(Lancet Diabetes Endocrinol. 2014年7月28日在线版)该项目为一项前瞻性队列研究,从亚洲9个国家或地区纳入41

中国香港中文大学Juliana C N Chan等公布的JADE项目表明,在亚洲成年2型糖尿病患者中,1/5为早发(40岁以前发病)型糖尿病。与迟发型2型糖尿病患者相比,早发型2型糖尿病患者的代谢危险因素控制较差,接受有利于器官保护的药物治疗者较少。(Lancet Diabetes Endocrinol. 2014年7月28日在线版)

该项目为一项前瞻性队列研究,从亚洲9个国家或地区纳入41 029例2型糖尿病患者。研究者发现,18%的受试者为早发型糖尿病患者,确诊平均年龄为32.9岁,而迟发型糖尿病患者的平均确诊年龄为53.9岁。早发型糖尿病患者的病程较长(10年 vs 5年);早发型糖尿病患者中HbA1c水平达到7%以下者比例明显低于迟发型糖尿病患者(27% vs 42%),前者的平均HbA1c水平、低密度脂蛋白胆固醇水平和视网膜病变患病率均显著高于后者,但接受他汀、肾素-血管紧张素系统抑制剂应用率明显低于后者。

原始出处:

Yeung RO1, Zhang Y1, Luk A2, Yang W3, Sobrepena L4, Yoon KH5, Aravind SR6, Sheu W7, Nguyen TK8, Ozaki R2, Deerochanawong C9, Tsang CC10, Chan WB11, Hong EG12, Do TQ13, Cheung Y14, Brown N15, Goh SY16, Ma RC1, Mukhopadhyay M17, Ojha AK18, Chakraborty S19, Kong AP1, Lau W2, Jia W20, Li W21, Guo X21, Bian R22, Weng J23, Ji L24, Rosa MR25, Toledo RM26, Himathongkam T27, Yoo SJ28, Chow CC2, Ho LL29, Chuang LM30, Tutino G1, Tong PC31, So WY2, Wolthers T15, Ko G1, Lyubomirsky G15, Chan JC32.Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme): a cross-sectional study of a prospective cohort.Lancet Diabetes Endocrinol. 2014 Jul 28. pii: S2213-8587(14)70137-8. doi: 10.1016/S2213-8587(14)70137-8. [Epub ahead of print]

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    2014-12-23 howi
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    2015-04-11 x35042875

    糖尿病肾病进展风险的关系没有发现。

    0

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