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Neurology:来自丹麦和瑞典的双国家队列研究:丧子之痛增加父母卒中发生风险,需更多社会支持与关注!

2022-02-19 Naomi MedSci原创

近日,有研究人员调查了失去子女的父母是否有更高的卒中风险,并分析造成相关风险差异的因素。研究发现,孩子去世与父母发生卒中的风险略有增加有关。这提示需要家庭成员和医疗保健专业人员提供更好的支持和关注。

      儿童死亡是一个极端的生活事件,对家庭有潜在的长期健康影响。越来越多的证据表明,经历过子女死亡的父母比未有相关经历的父母有更高的发病率和死亡率,包括心肌梗死、冠状动脉疾病、心室颤动、心力衰竭和心源性猝死。最近的一项系统综述表明,近亲的死亡与卒中风险的增加有关,然而,审查中包括研究中的大多数都集中在配偶的丧亲之痛上。到目前为止,只有一项研究调查了18岁以下儿童的死亡与卒中之间的关系,这可能是因为父母在随访结束时还太小不能经历卒中。

      近日,在一项以人群为基础的队列研究中,在长达39年的随访追踪中,有研究人员调查了失去子女的父母是否有更高的卒中风险,如果有的话,风险是否因孩子的死亡特征、死亡时间、家庭的社会人口因素或卒中的亚型而有所不同。

      研究人员进行了一项基于人口的队列研究,研究对象包括在1973-2016年或1973-2014年期间出生并分别记录在丹麦和瑞典医学出生登记册中的子女的父母。通过几个人口登记册之间的联系获得了有关儿童死亡、父母卒中以及社会经济和健康相关特征的信息。使用泊松回归来研究儿童死亡和卒中风险之间的联系。

  • 在6,711,955名研究参与者中,有128,744人(1.9%)在随访期间死亡,141,840人(2.1%)卒中。
  • 失去双亲者卒中危险性增加,相应的发病率比(95% 置信区间)为1.23(1.191.27)。在所有分析的儿童死亡原因(心血管疾病、其他自然死亡和非自然死亡)中,这种联系都存在,且并没有根据死亡子女的年龄而差异,但如果父母在丧子时没有子女或≥3个活着的子女,则强于1-2个活着的子女。
  • 缺血性和出血性卒中也有类似的联系。父母出血性卒中的风险在儿童死亡后立即达到最高值,之后降低。相反,在缺血性卒中的病例中,随着时间的推移并没有明显的模式。

      孩子去世与父母发生卒中的风险略有增加有关。在非自然死亡案例中观察到的联系的发现提示了丧亲相关的压力可能促进卒中发展的解释。虽然儿童的死亡往往无法避免,但了解其与健康有关的后果可能会突出表明,需要家庭成员和医疗保健专业人员提供更好的支持和关注。

文献来源:Wei D, Li J, Chen H, et al. Death of a Child and the Risk of Stroke: A Binational Cohort Study From Denmark and Sweden [published online ahead of print, 2022 Jan 7]. Neurology. 2022;10.1212/WNL.0000000000013263. doi:10.1212/WNL.0000000000013263

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    2022-10-15 yinhl1978
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    2022-02-21 医鸣惊人

    认真学习了

    0

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    2022-02-21 ms1000002133353315

    好!

    0

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术前缺血性卒中、高龄、心力衰竭和心肌梗死史与冠脉搭桥后POAF患者1年缺血性卒中风险相关。CHA2DS2-VASc和心房颤动评分预测卒中风险的准确性与非手术房颤队列相似。

Circulation:心房颤动患者的神经丝轻链水平与卒中风险之间的关系

NFL水平反映了未进行口服抗凝治疗的AF患者(包括无卒中史的患者)显性和隐性脑缺血发作,并改善了卒中和死亡的风险评估。

Stroke:心脏舒张功能障碍是非心源性栓塞性卒中患者复发血管事件的预测因素

LVDD 可能与非心肌栓塞性卒中后的进一步血管事件相关,这表明 LVDD 评估在非心肌栓塞性卒中患者的风险分层和二级预防中的重要性。

Cardiovasc Diabetol:甘油三酯-葡萄糖指数与高血压人群较高的卒中风险相关

在高血压人群中,基线TyG指数与首次卒中的风险显著升高相关。此外,年龄是这种关联的重要影响因素。

Eur Heart J:女性房颤患者的卒中风险

在CHA2DS2-VASc评分中,女性被赋予1分,因为女性与房颤患者较高的卒中风险相关。老年和心血管疾病可能部分解释了女性房颤患者较高的卒中发生率。

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