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Cell Death Dis:miR-143通过抑制HDAC7促进血管生成及成骨细胞的分化

2020-03-21 MedSci原创 MedSci原创

骨形成过程受成骨细胞及破骨细胞的数量及功能的直接调节,但目前调控骨形成过程及详细的调控机制仍不清楚。

骨形成过程受成骨细胞及破骨细胞的数量及功能的直接调节,但目前调控骨形成过程及详细的调控机制仍不清楚。

MicroRNA(miRNA)是一种单链非编码的约22个核苷酸的小RNA,参与基因的加工及调控生物过程,并通过结合mRNA的3'-UTR端调控其表达。

近期miRNA在骨形成过程中的作用引起了广泛关注,近期研究人员鉴定出一系列参与成骨分化及成骨细胞形成的miRNA。但miRNA在调节骨形成过程中的作用机制仍不清楚。

在该研究中,研究人员通过miRNA测序分析发现,miR-143是成骨细胞分化及CD31hiEMCNhi(一种特定的内皮血管亚型-H型血管)内皮细胞中的一种重要的miRNA,其在这两种细胞中均有表达。

研究人员发现血清miR-143表达水平与人类年龄呈负相关。过表达miR-143会促进成骨细胞的形成及血管的生成。此外,在miR-143敲除小鼠中,CD31hiEMCNhi血管及成骨细胞的形成均受到显著抑制。

机制研究发现,miR-143能够直接靶向抑制HDAC7,而敲低HDAC7的表达可以有效的挽救miR-143缺乏所引起的功能障碍。

综上研究结果表明,miR-143可以通过靶向HDAC7来促进血管生成与成骨细胞分化,而HDAC7或可作为血管生成性疾病及成骨性疾病的潜在靶标。

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    2021-01-09 docwu2019
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    2020-12-31 smallant2002
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    2020-04-01 lingaifan
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    2020-03-23 zhaojie88
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    2020-03-23 cy0328

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膀胱癌是最常见的和高度血管化的癌症之一。最近,有研究人员为了更好的理解该类型癌症的基因组结构和潜在的病因,对上皮膀胱恶性肿瘤(UBCs,最常见的膀胱癌类型)进行了全基因组测序和靶向测序。研究发现,影响基因调控元件和结构变异(SVs)且能干扰基因功能的复发性变异较为普遍。有意义的是,研究人员发现ADGRG6 增强子变异和FRS2拷贝数变异与肿瘤中更高的蛋白表达量和不良预后相关。功能分析阐释了UBC细

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血管生成对癌症的增殖和转移至关重要。然而,抗血管生成剂仅具有微弱的治疗疗效。先前的研究表明,microRNA(miR)-200家族通过调节肿瘤血管生成抑制肿瘤细胞的转移,但潜在的分子机制尚未阐明。来自北卡罗来纳大学Lineberger综合癌症中心研究人员使用整合的生物信息学方法,发现作为RNA结合蛋白(RBP)的QKI蛋白是miR-200b内皮靶标,其在肺癌肿瘤微环境中的研究尚未得到详尽的研究。此

J Endod:米诺环素和克林霉素毒性及成血管能力的比较评估:一项体外研究

这篇研究的目的是为了比较2种抗生素(克林霉素[CLIN]米诺环素[MINO])在不同浓度下对人牙髓干细胞(DPSCs)和人脐静脉内皮细胞(HUVECs)的细胞相容性和成血管潜力。

Blood:输血可逆转镰状细胞病的异常血管生成

中心点:缓慢的RBC流动和血管堵塞触发了HIF-1α诱导的异常血管生长的促血管生成环境。在SCD小鼠中,输血可逆转新血管的生成,突出了BM血管系统的可塑性。摘要:镰状细胞病(SCD)是一种高发病率、高死亡率的单基因红细胞病。本文首次报道了SCD对骨髓(BM)血管生态位(对造血至关重要)的影响。研究人员在SCD小鼠中发现了一个无组织的、结构异常的BM血管网络,该BM腔的大部分都是高度弯曲的小动脉,以

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