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JACC：利伐沙班安全性大型临床研究

2018-07-05 MedSci MedSci原创

心血管利伐沙班房颤卒中
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直接口服抗凝药（DOACs）用于预防房颤患者卒中发生风险的有效性已经取得验证，但大型前瞻性探究DOACs安全性的临床研究尚缺乏。本研究纳入了XANTUS和XANAP临床研究中的接受利伐沙班治疗预防卒中的房颤患者，随访时间为1年，主要终点事件是大出血事件、严重不良事件和全因死亡事件，次要终点事件是血栓栓塞事件和非大出血事件。最终共纳入11121名患者（平均年龄为70.5 ± 10.5，女性占42.9

直接口服抗凝药（DOACs）用于预防房颤患者卒中发生风险的有效性已经取得验证，但大型前瞻性探究DOACs安全性的临床研究尚缺乏。

本研究纳入了XANTUS和XANAP临床研究中的接受利伐沙班治疗预防卒中的房颤患者，随访时间为1年，主要终点事件是大出血事件、严重不良事件和全因死亡事件，次要终点事件是血栓栓塞事件和非大出血事件。最终共纳入11121名患者（平均年龄为70.5 ± 10.5，女性占42.9%），并发症包括心衰（21.2%）、高血压（76.2%）和糖尿病（22.3%），不良事件发生率（每100人年）为：大出血事件1.7（95% [CI]： 1.5 - 2.0），全因死亡事件1.9（95% CI： 1.6 - 2.2），卒中或系统性栓塞1.0（95% CI： 0.8 - 1.2）。另外，患者1年的治疗持续率为77.4%。

本大型前瞻队列研究结果显示，房颤患者接受利伐沙班治疗预防卒中的出血发生风险和卒中发生风险均较低。

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    2019-04-09 hbwxf

    #JACC#

    0

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    2018-07-17 jyzxjiangqin

    利伐沙班安全性临床研究.

    0

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    2018-07-09 jyzxjiangqin

    利伐沙班安全性临床研究.

    0

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    2018-07-07 131****1460

    学习了受益匪浅

    0

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    2018-07-07 12498568m50暂无昵称

    #ACC#

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    2018-07-06 131****1460

    学习了受益匪浅

    0

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    2018-07-05 惠映实验室

    学习了.谢谢分享.

    0

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    2018-07-05 清风拂面

    谢谢分享学习

    0

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    2018-07-05 1e0f8808m18(暂无匿称)

    利伐沙班预防房颤脑栓塞安全有效.

    0

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