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[GetTopicListResponse(id=2117834, encodeId=50f9211e8341a, content=激活<a href='/topic/show?id=afa5965438d' target=_blank style='color:#2F92EE;'>#铁死亡#</a>，增强<a href='/topic/show?id=370d8126914' target=_blank style='color:#2F92EE;'>#肝癌#</a><a href='/topic/show?id=daf52906537' target=_blank style='color:#2F92EE;'>#免疫治疗#</a>效果。这里使用的是铁死亡激活剂<a href='/topic/show?id=299e10542295' target=_blank style='color:#2F92EE;'>#Withaferin A#</a>。Withaferin A ，可以译为魏菲灵A或<a href='/topic/show?id=aab595622d5' target=_blank style='color:#2F92EE;'>#醉茄素A#</a>，是从<a href='/topic/show?id=eb2e1054234a' target=_blank style='color:#2F92EE;'>#睡茄#</a>中分离到的甾体内酯,可以对硫代*基化敏感的<a href='/topic/show?id=6b416398956' target=_blank style='color:#2F92EE;'>#氧化还原#</a>机制阻止<a href='/topic/show?id=3879828e19d' target=_blank style='color:#2F92EE;'>#肿瘤坏死因子#</a>诱导的IκB激酶β的激活，从而抑制<a href='/topic/show?id=f1c512e304f' target=_blank style='color:#2F92EE;'>#NF-kB#</a>的活性，靶作用于<a href='/topic/show?id=9d521054247a' target=_blank style='color:#2F92EE;'>#波形蛋白#</a> (vimentin),具有抗炎,<a href='/topic/show?id=2392556299f' target=_blank style='color:#2F92EE;'>#抗肿瘤#</a>等功效。Withaferin A 是<a href='/topic/show?id=5de210542595' target=_blank style='color:#2F92EE;'>#内皮蛋白C受体#</a>(EPCR)脱落的抑制剂。此前发现Withaferin A(WA)目前已被认为是一种<a href='/topic/show?id=f51fe4158e6' target=_blank style='color:#2F92EE;'>#神经保护剂#</a>，WA在<a href='/topic/show?id=a1f9485204d' target=_blank style='color:#2F92EE;'>#帕金森病#</a>中的神经保护作用的相关机制尚不清楚，现在看来可能与铁死亡有关, objectTitle=Gut：激活铁死亡，增强肝癌免疫治疗效果, objectType=article, longId=760992, objectId=4288e6099233, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20230226/1677425448720_5295905.jpg, objectUrl=/article/show_article.do?id=4288e6099233, replyNumber=0, likeNumber=193, createdTime=2023-03-06, rootId=0, userName=lifestar, userId=aa0e14, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=4288e6099233, moduleTitle=Gut：激活铁死亡，增强肝癌免疫治疗效果, 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href='/topic/show?id=f1c512e304f' target=_blank style='color:#2F92EE;'>#NF-kB#</a>, objectTitle=Bone：涉及炎症、NF-kB通路和肾素-血管紧张素-醛固酮系统的基因多态性与骨质疏松性骨折风险有关 , objectType=article, longId=214159, objectId=3de8214159fe, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=3de8214159fe, replyNumber=0, likeNumber=80, createdTime=2021-07-14, rootId=0, userName=jichang, userId=e2ca12754731, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=3de8214159fe, moduleTitle=Bone：涉及炎症、NF-kB通路和肾素-血管紧张素-醛固酮系统的基因多态性与骨质疏松性骨折风险有关 , moduleType=article, hrefUrl=//m.capotfarm.com/article/show_article.do?id=3de8214159fe)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1536961, encodeId=e194153696136, content=<a href='/topic/show?id=f1c512e304f' target=_blank style='color:#2F92EE;'>#NF-kB#</a>, objectTitle=Int Immunopharmacol：肠道微生物群通过调节TLR4/NF-kB信号通路对抗LPS引起的急性肺损伤, objectType=article, longId=214156, objectId=f054214156bc, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=f054214156bc, replyNumber=0, likeNumber=82, createdTime=2021-07-14, rootId=0, userName=jichang, userId=e2ca12754731, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=f054214156bc, moduleTitle=Int Immunopharmacol：肠道微生物群通过调节TLR4/NF-kB信号通路对抗LPS引起的急性肺损伤, moduleType=article, hrefUrl=//m.capotfarm.com/article/show_article.do?id=f054214156bc)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1536960, encodeId=ae861536960e5, content=<a href='/topic/show?id=f1c512e304f' target=_blank style='color:#2F92EE;'>#NF-kB#</a>, objectTitle=Blood：miR-146a类似物可治疗NF-kB驱动的炎症和白血病进展, objectType=article, longId=184507, objectId=fadc18450e72, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=fadc18450e72, replyNumber=0, likeNumber=124, createdTime=2019-12-11, 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GetTopicListResponse(id=1536957, encodeId=e5de153695e96, content=<a href='/topic/show?id=f1c512e304f' target=_blank style='color:#2F92EE;'>#NF-kB#</a>, objectTitle=J immunol：NF-KB参与抗HBV感染天然免疫反应, objectType=article, longId=71007, objectId=7161e10071c, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=7161e10071c, replyNumber=0, likeNumber=115, createdTime=2016-06-18, rootId=0, userName=jichang, userId=e2ca12754731, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=7161e10071c, moduleTitle=J immunol：NF-KB参与抗HBV感染天然免疫反应, moduleType=article, hrefUrl=//m.capotfarm.com/article/show_article.do?id=7161e10071c)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1536956, encodeId=40f41536956db, content=<a href='/topic/show?id=f1c512e304f' target=_blank style='color:#2F92EE;'>#NF-kB#</a>, objectTitle=J immunol：MMP-25 金属蛋白酶调节NF-KB信号, objectType=article, longId=70621, objectId=006de0621d1, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=006de0621d1, replyNumber=0, likeNumber=98, createdTime=2016-06-14, rootId=0, userName=jichang, userId=e2ca12754731, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=006de0621d1, moduleTitle=J immunol：MMP-25 金属蛋白酶调节NF-KB信号, moduleType=article, hrefUrl=//m.capotfarm.com/article/show_article.do?id=006de0621d1)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1536955, encodeId=18e0153695590, content=<a href='/topic/show?id=f1c512e304f' target=_blank style='color:#2F92EE;'>#NF-kB#</a>, objectTitle=胡洪波博士：泛素化和非经典NF-kB信号通路在免疫反应和肿瘤免疫中的功能, objectType=article, longId=68338, objectId=2df96833812, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=2df96833812, replyNumber=0, likeNumber=99, createdTime=2016-05-18, rootId=0, userName=jichang, userId=e2ca12754731, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=2df96833812, moduleTitle=胡洪波博士：泛素化和非经典NF-kB信号通路在免疫反应和肿瘤免疫中的功能, moduleType=article, hrefUrl=//m.capotfarm.com/article/show_article.do?id=2df96833812)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1536954, encodeId=c49f153695446, content=<a href='/topic/show?id=f1c512e304f' target=_blank style='color:#2F92EE;'>#NF-kB#</a>, objectTitle=Cancer：NF-kB多态性与肺癌发病风险降低相关, objectType=article, longId=12751, objectId=ca5f12e51d4, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=ca5f12e51d4, replyNumber=0, likeNumber=137, createdTime=2012-12-12, rootId=0, userName=仁医06, userId=55683, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=ca5f12e51d4, moduleTitle=Cancer：NF-kB多态性与肺癌发病风险降低相关, moduleType=article, hrefUrl=//m.capotfarm.com/article/show_article.do?id=ca5f12e51d4)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

NF-kB

2020-05-29

lifestar (审核中...)

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全文收起激活#铁死亡#，增强#肝癌##免疫治疗#效果。这里使用的是铁死亡激活剂#Withaferin A#。Withaferin A ，可以译为魏菲灵A或#醉茄素A#，是从#睡茄#中分离到的甾体内酯,可以对硫代*基化敏感的#氧化还原#机制阻止#肿瘤坏死因子#诱导的IκB激酶β的激活，从而抑制#NF-kB#的活性，靶作用于#波形蛋白# (vimentin),具有抗炎,#抗肿瘤#等功效。Withaferin A 是#内皮蛋白C受体#(EPCR)脱落的抑制剂。此前发现Withaferin A(WA)目前已被认为是一种#神经保护剂#，WA在#帕金森病#中的神经保护作用的相关机制尚不清楚，现在看来可能与铁死亡有关

Gut：激活铁死亡，增强肝癌免疫治疗效果

2023-03-06发表于上海

jichang (审核中...)

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#NF-kB#

Clin Immunol：HBV通过NF-Kb途径参与肝病的进展

2021-07-14

jichang (审核中...)

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#NF-kB#

Bone：涉及炎症、NF-kB通路和肾素-血管紧张素-醛固酮系统的基因多态性与骨质疏松性骨折风险有关

2021-07-14

jichang (审核中...)

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#NF-kB#

Int Immunopharmacol：肠道微生物群通过调节TLR4/NF-kB信号通路对抗LPS引起的急性肺损伤

2021-07-14

jichang (审核中...)

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#NF-kB#

Blood：miR-146a类似物可治疗NF-kB驱动的炎症和白血病进展

2019-12-11

jichang (审核中...)

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#NF-kB#

Front Pharmacol：黄芩苷可通过抑制TLR4的表达和NF-kB活化对抗LPS诱导的肝脏炎症

2017-10-05

jichang (审核中...)

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#NF-kB#

Immunity：细菌DNA环状双核苷酸同时诱导I型干扰素产生和激活转录因子NF-KB

2017-03-25

jichang (审核中...)

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#NF-kB#

J immunol：NF-KB参与抗HBV感染天然免疫反应

2016-06-18

jichang (审核中...)

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#NF-kB#

J immunol：MMP-25 金属蛋白酶调节NF-KB信号

2016-06-14

jichang (审核中...)

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#NF-kB#

胡洪波博士：泛素化和非经典NF-kB信号通路在免疫反应和肿瘤免疫中的功能

2016-05-18

仁医06 (审核中...)

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#NF-kB#

Cancer：NF-kB多态性与肺癌发病风险降低相关

2012-12-12

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