帕尼单抗-话题@MedSci - 梅斯（MedSci）

#帕尼单抗#

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帕尼单抗

2020-05-29

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#帕尼单抗# #转移性结直肠癌# #KRAS G12C突变# #索托拉西布#

Nat. Med | 索托拉西布联合帕尼单抗治疗化疗难治性KRAS G12C突变结直肠癌：一项1b期试验

2024-02-24发表于上海

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#化疗# #结直肠癌# #帕尼单抗# #索托雷塞#

Nat Med：化疗难治性KRAS G12C结直肠癌应用索托雷塞+帕尼单抗，最新数据公布

2024-01-28发表于陕西省

侠胆医心 (审核中...)

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全文收起治疗#KRAS G12C突变#的难治性#结直肠癌#患者，经过中位7.8个月随访，960 mg#索托拉西布#+#帕尼单抗#组和240 mg索托拉西布+帕尼单抗组的中位无进展生存期分别为5.6个月和3.9个月，而标准治疗组为2.2个月。整体而言，治疗的难度还是相当大的，对这些难治性的，未来还需要更多的手段。

NEJM：治疗KRAS G12C突变的难治性结直肠癌患者，索托拉西布联合帕尼单抗或可延长无进展生存期

2023-10-31发表于加利福尼亚

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#帕尼单抗#

J Clin Oncol：mFOLFOXIRI+帕尼单抗对比FOLFOX+帕尼单抗一线治疗RAS和BRAF野生型转移性结直肠癌(mCRC)的疗效

2022-06-17

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#帕尼单抗#

J Clin Oncol：mFOLFOXIRI方案联合帕尼单抗治疗RAS/BRAF野生型转移性结直肠癌

2022-06-16

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#帕尼单抗#

J Clin Oncol：氟尿嘧啶/亚叶酸联合帕尼单抗维持治疗可显著延长RAS野生型转移性结直肠癌患者的生存期

2021-12-02

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#帕尼单抗#

J Clin Oncol：氟尿嘧啶/亚叶酸联合帕尼单抗维持治疗可显著延长RAS野生型转移性结直肠癌患者的生存期

2021-09-20

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#帕尼单抗#

NEJM：帕尼单抗相关的睫毛伸长-病例报道

2020-10-16

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#帕尼单抗#

Medicine：帕尼单抗补充治疗可一定程度上改善WT KRAS的结直肠癌患者的客观反应，但会增加不良事件的发生率

2020-08-04

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#帕尼单抗#

JAMA Oncol：VALENTINO研究：帕尼单抗一线维持治疗RAS野生型结直肠癌劣于帕尼单抗联合氟尿嘧啶

2019-07-16

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#帕尼单抗#

CLIN CANCER RES：循环肿瘤DNA出现RAS紧急突变对帕尼单抗治疗转移性结直肠癌的影响

2018-11-24

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#帕尼单抗#

EUR J Cancer：帕尼单抗联合顺铂/吉西他滨治疗KRAS野生型胆管癌

2018-03-02

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#帕尼单抗#

Br J Cancer：野生型KRAS或RAS转移性结直肠癌：帕尼单抗联合更佳支持治疗

2016-10-22

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#帕尼单抗#

Clin Cancer Res：帕尼单抗联合吉西他滨放化疗用于局部晚期胰腺癌的I期临床研究

2015-06-15

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#帕尼单抗#

Lancet Oncol：二期临床发现帕尼单抗不适用于晚期头颈部鳞癌

2015-01-25

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#帕尼单抗#

CCC：帕尼单抗或贝伐单抗联合FOLFIRI方案二线治疗转移性结直肠癌疗效比较(SPIRITT研究）

2015-01-12

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#帕尼单抗#

Int J Radiat Oncol Biol Phys：术前放化疗结合帕尼单抗治疗可切除食管癌：2期临床试验

2014-11-19

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#帕尼单抗#

Lancet Oncol：帕尼单抗对KRAS野生型转移性结直肠癌非劣于西妥昔单抗（ASPECCT研究）

2014-04-30

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