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AJG: 性别不再是非酒精性脂肪性肝病的女性心血管疾病的保护因素

2019-11-30 不详 MedSci原创

心血管(CV)疾病是非酒精性脂肪肝(NAFLD)患者死亡的首要原因,而女性可以预防心血管疾病。本项研究旨在确定女性在NAFLD中是否仍然是预防心血管疾病(心肌梗塞,心绞痛和中风)的保护因素。

目的:
血管(CV)疾病是非酒精性脂肪肝(NAFLD)患者死亡的首要原因,而女性可以预防血管疾病。本项研究旨在确定女性在NAFLD中是否仍然是预防心血管疾病(心肌梗塞,心绞痛和中风)的保护因素。

方法:
研究人员确定了1997年至2014年之间在明尼苏达州奥尔姆斯特德县诊断为NAFLD的所有成年人,并从总人群中选择了年龄和性别相匹配的(1:4)参照人群。使用Cox比例风险回归分析(按标准临床风险因素进行分层)检查了女性对事件CV事件的影响。

结果:
本项研究总共确定了3869名NAFLD和15209名年龄和性别匹配的参照对象。中位随访时间为7年,总共记录到了3851个CV事件发生。在一般人群中,女性对缺血性CV事件具有保护作用(危险比= 0.71,95%置信区间0.62-0.80,P <0.001),但在患有NAFLD的人群中,这种影响显着减少(危险比= 0.90,95%可信度0.74–1.08,P= 0.25)。在患有NAFLD的人群中,女性的不良事件高于男性:心血管疾病(18% VS 9%)和死亡率(9% VS 6%)。

讨论:
患有NAFLD的女性失去了性别赋予的CV保护。

原始出处:
Allen, Alina. Et al. Women With Nonalcoholic Fatty Liver Disease Lose Protection Against Cardiovascular Disease. American Journal of Gastroenterology. 2019.

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    2020-06-08 minzju5052
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    2020-07-01 qjddjq
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    2019-12-02 苏小雨

    学习了谢谢分享

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