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Nat Commun:抑制这种蛋白,“一键调节”焦虑症状

2019-01-05 探索君 生物探索

当下,焦虑正成为不少人都避不开的一种情绪。

当下,焦虑正成为不少人都避不开的一种情绪。

无论何种类型的焦虑,对身心无疑都是不利的,严重者甚至会产生惊恐发作等精神症状。在极端情况下,焦虑障碍患者人几乎足不出户,对家人和朋友的关系以及自身的生活产生严重后果。

据统计,大约10%的人都会有焦虑症,而目前的治疗方案通常为药物治疗和心理治疗,但都仍有部分患者不能得到有效的帮助。科学家也一直在寻找抗焦虑药物的新的、更具体的靶点。

IgSF9b,抗焦虑药物新靶点?

根据近日一项新研究,科学家鉴定出了一种IgSF9b突触蛋白,当它失活时,对小鼠有抗焦虑作用。

具体来说,在进行小鼠动物试验时,研究人员发现,健康的动物会好奇地“探寻”空试验箱,而患有焦虑症的啮齿动物会因为害怕而退缩至角落。然而,当科学家在小鼠中阻断IgSF9b时,这些动物的焦虑行为变得正常化。因此,主要作者,Max Planck实验医学研究所的Olga Babaev认为,IgSF9b这种蛋白质可以成为治疗焦虑症的药理学方法的目标。

我们期待,这项研究的新发现能早日开展临床试验,为抗焦虑新药的研发带来新途径。

原始出处:
Olga Babaev, Hugo Cruces-Solis, Carolina Piletti Chatain, et al. IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses. Nature Communications. Dec 2018.

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    2019-11-11 liuli5079
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    2019-04-23 liye789132251
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    2019-01-06 一天没事干

    很好的学习机会

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2087492, encodeId=c931208e4927f, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Mon Nov 11 06:30:00 CST 2019, time=2019-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1883511, encodeId=81db1883511af, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Tue Apr 23 08:30:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357348, encodeId=3bee35e348f3, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Sun Jan 06 11:18:17 CST 2019, time=2019-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050481, encodeId=e3a810504812a, content=焦虑是当年年轻人的共同问题,需要认真对待。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Sat Jan 05 13:30:00 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-01-05 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

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