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JAMA Surg:肌肉减少症和脑萎缩是评估老年人创伤预后的重要指标

2019-05-14 MedSci MedSci原创

老年创伤患者的咬肌肌肉减少症和脑萎缩与1年死亡率相关

老年人创伤后的恢复效果显著低于其他人群,据统计2016年创伤死亡占老年人死亡的47%。多数创伤患者的不良临床结果的危险因素包括肌肉减少症和脑萎缩。近日研究人员利用CT,考察了65岁以上创伤患者的咬肌肌肉减少症和脑萎缩与1年死亡率的关系。

研究于2011-14年开展,华盛顿州65岁以上的,因创伤接受ICU治疗患者参与研究,患者头部损伤评分低于3分,采用标准临床手段评估咬肌横截面积和脑萎缩指数,随访一年,研究的主要终点为1年死亡率。次要结果为出院情况和30天死亡率

327例患者,72例(22.0%)仅伴有肌肉减少症,71例(21.7%)脑萎缩,92例(28.1%)两者兼有,92例(28.1%)两者均无,平均年龄77.8岁,女性159例(48.6%)。经年龄、共病、并发症和损伤特征调整后,咬肌层减少和脑萎缩与死亡率呈独立和累积相关(咬肌肌肉横截面积低于平均每SD的HR为2.0,95%CI:1.2-3.1,P=0.005;脑萎缩指数大于平均每SD的HR为2.0,95%CI:1.1-3.5,P=0.02)。

研究认为,老年创伤患者的咬肌肌肉减少症和脑萎缩与1年死亡率相关。

原始出处:


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PLos One:组织学亚型与肺癌中的肌肉减少症无关

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Baidu
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Baidu
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