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J Clin Periodontol: :血糖水平对糖尿病患者龈下微生物的影响

2018-08-18 MedSci MedSci原创

牙周炎与2型糖尿病(T2DM)相关,但目前的研究对牙周炎相关的龈下微生物群与血糖水平的关系知之甚少。本研究评估了T2DM患者的牙周微生物与血糖水平的关系。

牙周炎与2型糖尿病(T2DM)相关,但目前的研究对牙周炎相关的龈下微生物群与血糖水平的关系知之甚少。本研究评估了T2DM患者的牙周微生物与血糖水平的关系。

根据全身血糖状况,将21例慢性牙周炎和体重指数≤40kg/ m2的T2DM非吸烟患者分为两组:不足(DMI-HbA1c≥8%)和充足(DMA-HbA1c <7.8%) 。在口内的两个象限中的中度(PD = 4-6mm)和重度(PD≥7mm)牙周炎的位点收集龈下生物膜。使用GS-FLX-454 Titanium平台对16SrRNA的V5-V6高变区进行测序。使用QIIME和PhyloToAST将序列与HOMD数据库进行比较。使用双样本t检验进行统计学比较。

结果:DMA组微生物组比DMI多样性更高。血糖控制不足有利于发酵菌种,特别是那些与丙酸/琥珀酸生产相关的菌种,而那些形成丁酸盐/丙酮酸盐的物质在DMI中降低。 DMI中较高丰度的anginosus和Streptococcus agalactiae可能表明龈下位点是潜在侵入性病原体的储库。改变 DMI中龈下微生物可能是这些患者的牙周治疗和预防的一个新思路。

结论:T2DM患者的血糖水平似乎与龈下生物膜组成相关。

原始出处:

Priscila L. Longo, et al. Glycaemic status affects the subgingival microbiome of diabetic patients. Journal of Clinical Periodontology. 2018 August. doi: 10.1111/jcpe.12908

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    2018-12-09 feather89
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  4. 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  5. 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    2018-08-19 ren1mw

    学习一下

    0

  6. 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    2018-08-19 深海的鱼

    学习学习学习

    0

  7. 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  8. 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    2018-08-19 misszhang

    谢谢MedSci提供最新的资讯

    0

  9. 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    2018-08-19 phoebeyan520

    学习了

    0

  10. 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    2018-08-19 布范斯医生

    学习了

    0

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在EASD 2014上公布的一项针对SAVOR-TIMI 53研究的最新分析显示,在2型糖尿病患者中,低血糖事件发生情况存在明显的性别差异,男性发生低血糖事件的次数更高,而女性更可能报告低血糖相关症状。上海第六人民医院贾伟平教授等参与了这项最新分析。(壁报摘要号:483) SAVOR-TIMI 53研究纳入16 492例2型糖尿病患者,随机给予沙格列汀或安慰剂治疗,中位随访2.1年。这项

JCEM:不同表型糖尿病前期与2型糖尿病患者胰岛素抵抗与β细胞功能障碍的关联研究

研究背景: 使用HbA1c或血糖水平作为诊断依据诊断的糖尿病少有交叉,并且对于HbA1c诊断识别哪些病理生理缺陷仍然不明。 研究目的: 我们对不同表型亚分类的糖尿病前期和2型糖尿病患者的胰岛素敏感性及β细胞功能进行了检测并分析相关性。 研究设计: 我们开展了一项基于丹麦人群ADDITION-PRO研究的横断面研究(n=1713)。既往无糖尿病病史的受试者在接受检测后根

Cell:重磅!控制细胞定时分裂的蛋白也参与调节血糖水平

2016年7月3日/生物谷BIOON/--在一项新的研究中,来自美国德州大学西南医学中心(UTMC)的研究人员发现在细胞分裂定时控制中发挥着关键作用的蛋白也参与调节血糖水平。相关研究结果于2016年6月30日在线发表在Cell期刊上,论文标题为“Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Home

Diabetologia:吸烟对不同血糖指标的影响可能存在差异

研究要点: 该研究比较当前吸烟者、曾经吸烟者和从未吸烟者的糖化血红蛋白、空腹血糖和餐后2小时血糖;发现当前吸烟者的糖化血红蛋白高于从未吸烟者,而餐后2小时血糖低于从未吸烟者。 吸烟与血糖变量之间的关系目前尚未阐明。为了比较当前吸烟者、曾经吸烟者和从未吸烟者的糖化血红蛋白(HbA1c)、空腹血糖(FPG)和餐后2小时血糖(2H-PG),来自法国巴黎第十一大学的Beverley 

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